Registration Dossier
Registration Dossier
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EC number: 203-104-6 | CAS number: 103-36-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The report of the study does not include a lot of information regarding the methodology and results, therefore, it is unclear whether the study was well conductucted and it is not possible to assign a reliability code.
Data source
Reference
- Reference Type:
- other: unpublished report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Ethyl cinnamate
- EC Number:
- 203-104-6
- EC Name:
- Ethyl cinnamate
- Cas Number:
- 103-36-6
- Molecular formula:
- C11H12O2
- IUPAC Name:
- .
- Details on test material:
- - Appearance: clear liquid
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 2.56 g/kg bw, 3.20 g/kg bw, 4.0 g/kg bw, 5.0 g/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 200 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- other: The animals that died experienced sluggishness prior to death.
Any other information on results incl. tables
|
Observation Days |
|
||||||
Dose (oral) |
1 |
2 |
3 |
4 |
5 |
6 |
7-14 |
SUM |
2.56 g/kg |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 / 10 |
3.20 g/kg |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
2 / 10 |
4.00 g/kg |
6 |
1 |
0 |
0 |
0 |
0 |
0 |
7 / 10 |
5.0 g/kg |
8 |
1 |
0 |
0 |
0 |
0 |
0 |
9 / 10 |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of the test item was found to be > 3.2 g/kg bw.
- Executive summary:
In the current study it is unclear which method was used to determine the acute oral toxicity of the test item.
It is to be noted that the conclusion mentioned in the test report is an LD50 of 7.8 g/kg. This does not match the mortality scores per dose as tabulated in the test report. Based on the mortality scores, an LD50 > 3.2 g/kg bw is found. For precautionary reasons, the lower LD50 value is retained for the purpose of the registration dossier.
As this is > 2000 mg/kg bw, the substance should not be classified according to the CLP Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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