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EC number: 203-551-7 | CAS number: 108-11-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In standard primary irritation studies in rabbits, MIBC is was irritating to skin and the eyes. Human volunteers exposed to MIBC vapors at 50 ppm experienced eye irritation in most subjects with nose and throat irritation experienced at higher concentrations. The maximum tolerable concentration was considered to be 25 ppm.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
A skin irritation study on methyl iso butyl carbinol has been performed in accordance with OECD Guidelines for the Testing of Chemicals No. 404 and in compliance with GLP (Parcell, 1998). In this study, 3 New Zealand White rabbits were exposed to 0.5 mL of undiluted methyl iso butyl carbinol on the clipped dorsal lumbar region under semi-occlusive conditions. Animals were exposed to the test compound for 4 hours and observations were recorded at 1, 24, 48, and 72 hours after removal of the patch and residual test substance. Additional daily observations were made up to a maximum of 14 days. Skin reactions were scored according to a prescribed numerical system. In all 3 animals, well-defined erythema with slight edema was observed. In addition, desquamation of the stratum corneum, characterized by dryness and sloughing of the skin, developed in all animals. In one rabbit, thickening of the skin was observed. Dermal responses were fully resolved by either Day 10 or 12 in 2 animals. However, very slight erythema was still observed in one animal at Day 14. No signs of toxicity or ill health were observed in any rabbit during the observational period. The individual mean scores over 24, 48 and 72 hours were 2.0, 2.0 and 2.0 for erythema and 2.0, 1.0 and 1.7 for edema.
Eye Irritation:
An eye irritation study on methyl iso butyl carbinol has been performed in accordance with OECD Guidelines for the Testing of Chemicals No. 405 and in compliance with GLP (Parcell, 1998). In this study, 0.1 mL of undiluted methyl iso butyl carbinol was instilled into one conjunctival sac of each of 3 New Zealand White rabbits. Ocular changes were assessed 1, 4.5, 24, 48, 72 hours after treatment, and additional daily observations were made up to a maximum of 14 days. Eye irritation reactions were observed and scored according to guideline methods. No clinical signs of systemic toxicity or ill health were observed in any rabbit during the course of the study. Corneal opacification (Grade 1 or 2), iridial inflammation (Grade 1), and a diffuse beefy red or crimson coloration of the conjunctivae and swelling with eyelids about half-closed were observed in all animals. These effects were resolved within 7 or 14 days after instillation. Under the conditions of this study, methyl iso butyl carbinol induced corneal opacification, iridial inflammation, and conjunctival irritation. Individual mean scores over 24, 48 and 72 hours were 1.0, 0.7 and 2.0 for corneal opacity, 0.7, 0.7 and 0.3 for iritis, 2.3, 1.3 and 1.3 for conjunctival redness and 1.0, 0.3 and 0.3 for chemosis.
Respiratory tract irritation
A study with human volunteers (12/sex) indicated that vapor exposure to MIBC at 50 ppm for 15 minutes resulted in eye irritation in most subjects with nose and throat irritation experienced at higher concentrations. The maximum tolerable concentration was considered to be 25 ppm (Silverman et al., 1946).
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Regulation (EC) No 1272/2008
- Annex VI Table 3.1
Classification |
Labelling |
|||
Hazard Class |
Hazard Statement |
Pictogram |
Hazard Statement |
Suppl. Hazard |
STOT SE 3 |
H335 |
GHS07 |
H335 |
- Annex VI Table 3.2
Classification |
Risk phrases |
Indication(s) of danger |
Xi; R37 |
37 |
Xi |
Self-classification
-Regulation (EC) No 1272/2008
Classification |
Labelling |
|||
Hazard Class |
Hazard Statement |
Pictogram |
Hazard Statement |
Suppl. Hazard |
Eye Irrit. 2 STOT SE 3 |
H319 H335 |
GHS07 |
H319 H335 |
- Directive 67/548/EEC
Classification |
Risk phrases |
Indication(s) of danger |
Xi; R36/37/38 |
36/37/38 |
Xi |
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