Registration Dossier
Registration Dossier
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EC number: 206-058-5 | CAS number: 298-12-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 08-02-2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- QSAR prediction
- Qualifier:
- according to guideline
- Guideline:
- other: calculated with PC KOW WIN 1.67a (2008). Developed by US-EPA and recommended by ECHA
- GLP compliance:
- no
- Type of method:
- calculation method (fragments)
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- -0.7
- Temp.:
- 25 °C
- pH:
- ca. 0.3
- Remarks on result:
- other: log Pow for the hydrated form; pH is for Glyoxylic Acid 50%
- Type:
- log Pow
- Partition coefficient:
- -1.4
- Temp.:
- 25 °C
- pH:
- ca. 0.3
- Remarks on result:
- other: log Pow for the anhydrous form; pH is for Glyoxylic Acid 50%
- Executive summary:
The log Kow could not be determined experimentally because Glyoxylic Acid 50% reacted with n-octanol during the test forming a hemiacetal.
Therefore, PC KOW WIN 1.67a (2008) was used to calculate log Kow value of - 0.7 and - 1.4 for hydrated and anhydrous Glyoxylic Acid, respectively. This is in accordance with REACH Annex VII, column 2.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 22-01-1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Details on results:
- Partition coefficient was not measurable as glyoxylic acid forms hemiacetal with n-octanol as shown by acidimetry and polarography.
- Executive summary:
Partition coefficient was not measurable as glyoxylic acid forms hemiacetal with n-octanol as shown by acidimetry and polarography.
Referenceopen allclose all
Description of key information
Log Kow value of - 0.7 and - 1.4 for hydrated and anhydrous Glyoxylic Acid, respectively.
Key value for chemical safety assessment
- at the temperature of:
- 20 °C
Additional information
The log Kow could not be determined experimentally because Glyoxylic Acid reacted with n-octanol during the test forming a hemiacetal.
Therefore, PC KOW WIN 1.67a (2008) was used to calculate log Kow value of - 0.7 and - 1.4 for hydrated and anhydrous Glyoxylic Acid, respectively. This is in accordance with REACH Annex VII, column 2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
