Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 200-909-4 | CAS number: 75-86-5
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo
- Adequacy of study:
- other information
Data source
Reference
- Title:
- No information
- Author:
- Monsanto Co. (1983) |Report HL-83-195|In-vivo bone marrow chromosome study in rats.|US EPA/OPTS Public files No. 878216400
Materials and methods
- Principles of method if other than guideline:
- Method: other: US EPA Health Effects guidelines, EPA Report 560/5-83-001.
- GLP compliance:
- yes
- Type of assay:
- other: In vivo cytogenetics chromosomes abberation assay.
Test material
- Reference substance name:
- 2-hydroxy-2-methylpropionitrile
- EC Number:
- 200-909-4
- EC Name:
- 2-hydroxy-2-methylpropionitrile
- Cas Number:
- 75-86-5
- Molecular formula:
- C4H7NO
- IUPAC Name:
- 2-hydroxy-2-methylpropanenitrile
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
TS-Freetext:
98.5% Acetone cyanohydrin. Certificate of analysis.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: gavage
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1.5 & 15 mg/kg
Basis:
Results and discussion
Applicant's summary and conclusion
- Executive summary:
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Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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