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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-860-9 | CAS number: 75-31-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
The substance has a low adsorption potential on soil (Koc: 43.2 L/kg). Volatility from water or moist soil will be low as well based on a Henry's law constant of 0.001615 Pa*m^3/mol (SPARC; pH 7; 25°C).
Additional information
There is no substantial adsorption potential to soil, based on the very low partition coefficient as well as ready biodegradability. Experimental Koc values were obtained with n-butylamine (source), a structure-analogous short-chain alkylamine [CAS no. 109-73-9]. From a reliable batch equilibrium test a very low potential for adsorption was determined based on three very different soils (2 soils, one sediment) with regard to pH, organic carbon content, sand, silt and clay content.
Overall result: Koc (geometric mean over three matrices) = 43.2 L/kg (Koc-range: 33.8 to 65.6 L/kg).
With a pKa of 10.8, isopropylamine will exist predominantly in its protonated form in the environment, and the protonated form of isopropylamine is not expected to volatilize from water or moist soil surfaces. Therefore, common estimation methods (including estimation from water solubility and vapour pressure) will overestimate volatility considerably. Therefore, SPARC was used to calculate Henry's law constant as a function of pH. The resulting Henry's law constant (SPARC; pH 7; 25°C) of 0.001615 Pa*m^3/mol confirms the assumed very low volatility in the environmentally relevant pH range.
In conclusion, isopropylamine will neither to any relevant extent adsorb to the solids fraction of STP sludge, water, sediment or soil, nor volatilize from water or moist soil. It will be found predominantly in the water phase.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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