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Diss Factsheets
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EC number: 200-860-9 | CAS number: 75-31-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Classification requirements for the submission substance with regard to physico-chemical properties:
Flammable liquid category 1 (H224: Extremely flammable liquid and vapour).
Relevant key information for each endpoint is given in the endpoint summaries on the respective properties.
For a summary and conclusion with regard to overall physical hazards and respective classification and labelling requirements, see below.
Additional information
A full set of physico-chemical information is available with all of the essential parameters determined according to established testing guidelines. Classification issues are discussed in the relevant endpoint summaries in more detail. Here, only a brief summary is given:
Based on a flash point <23°C (-37 °C) and a boiling point <35°C (32 °C at 1013 hPa), the submission substance is classified according to REGULATION (EC) No. 1272/2008 (CLP) as well as UN-GHS rev. 7 (2017) as
Flammable liquid category 1 (H224: Extremely flammable liquid and vapour).
The following explosive limits for isopropylamine (range between the lowest and highest concentrations of vapour in air that will burn or explode) were determined:
lower limit: 4.2 vol.% - upper limit: 13.9 vol.%.
Pyrophoric properties as well as formation of flammable gases in contact with water can be excluded based on experience from the handling and use of the substance.
With regard to self-heating, according to (1) "In general, the phenomenon of self-heating applies only to solids. The surface of liquids is not large enough for reaction with air and the test method is not applicable to liquids. Therefore liquids are not classified as self-heating."
Self-reactiveness as well as explosiveness could reliably be excluded by structural considerations: there are no chemical groups present in the molecule associated with explosive or self reactive properties. Examples of such groups are given in Tables A6.1 and A6.2 in Appendix 6 of the UN Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria (2).
According to criteria given by REGULATION (EC) No. 1272/2008 (CLP) Annex I, section 2.13.4.1. regarding oxidising properties, the substance is incapable of reacting exothermically with combustible materials on the basis of the chemical structure. As such, there are no classification requirements regarding oxidising properties.
In addition, classification for corrosiveness to metals was checked. According to (1), corrosiveness to metals may be relevant for substances with acidic or basic functional groups, substances containing halogen or substances able to form complexes with metals. The submission substance is a base (amine) with an experimentally determined pKa of 10.8 and thus a candidate for metal corrosion. However, testing is not necessary if a substance is corrosive to skin according to the UN Manual of Tests and Criteria, section 37.1.1 (rev. 6, 2015). The submission substance is classified as Skin Corr. 1A (self-classification). As such, a test on metal corrosion is not required. However, supporting information was identified:
Xhanari et al. (2017) performed immersion tets with C15-grade mild steel in solutions of pure water containing 3 wt% NaCl as corrosion enhancer as well as 0.1 and 1 wt% isopropylamine, respectively.
Based on these experiments GHS criteria are definitely not met with regard to steel corrosion of aqueous solutions of ispropylamine. Rather, isopropylamine is acting as corrosion inhibitor (steel) with the size of inhibition effect being positively correlated with temperature and concentration. According to this, metal corrosion of pure isopropylamine is highly unlikely. This is confirmed by experience from handling and use of the substance, which does not indicate any relevant corrosion to metals. Therefore, the substance is not classified for this endpoint.
Overall, the substance has to be classified as flammable liquid Cat. 1. No other classification requirements with regard to physical hazards do exist.
(1) Guidance on the Application of the CLP Criteria; ECHA-17-G-21-EN, July 2017
(2) UN Manual of Tests and Criteria; Sixth revised edition; United Nations 2015; Appendix 6 SCREENING PROCEDURES
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.