Registration Dossier
Registration Dossier
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EC number: 205-743-6 | CAS number: 149-57-5
Endpoint summary
Administrative data
Description of key information
According to the results of valid GLP OECD Guideline studies, 2-EHA is slightly irritating to the skin and the eyes. Based on these results it is concluded that 2-EHA vapor is non to slightly irritating to the repiratory tract as well.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Valid animal studies concerning irritating properties are available for 2-EHA.
0.5 ml 2-EHA was applied to the shaved flank of 3 New Zeeland white rabbits in a GLP OECD 404 guideline conform skin irritation study. The test substance was washed off after 4 h exposure with lukewarm tap water. The 24 – 72 h mean values are 0.66 (erythema) and 0.33 (edema). Edema score was 0 at day 7 but raised to a grade 1 in one animal and grade 2 in another animal at day 14. Erythema and eshar formation was still visible after 14 days. Because edema was gone at day 7 and returned afterwards it may concluded that scratching occurred. The overall assumption is that 2-EHA is only slightly irritating.
In a GLP OECD 405 guideline study 100 µl 2-EHA was applied to one eye of 3 New Zeeland white rabbits. The other eye served as control. The average score (24 to 72 hours) for irritation was calculated to be 0.44 for corneal opacity, 0.56 for iris, 1.2 for conjunctival redness and 0.89 for chemosis . The findings were reversible in all animals within 7 days after application. Considering the described findings, 2-EHA is slightly irritant to the eye.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
The classification criteria according to EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances (annex I) and Mixtures (CLP) Regulation (EC) No. 1272/2008 are not met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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