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Diss Factsheets
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EC number: 204-699-5 | CAS number: 124-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to birds: reproduction test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test compound has been administered to hen eggs, both by injection into the yolk sac and by diffusion through the shell.
- GLP compliance:
- no
- Dose method:
- other: injection or diffusion
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: hen eggs from Light Sussex hens and White Leghorn X White Leghorn/Rhode Island Red Strain
- Details on test organisms:
- TEST ORGANISM
- Source: Messrs. Needls, Cuffley, Herts. and Y. Watanabé Ltd, Hatchford, Surrey) - Remarks:
- max. 10 sec. in diffusion tests
- No. of animals per sex per dose and/or stage:
- up to 96 hen eggs
- Control animals:
- yes
- Endpoint:
- long-term toxicity to birds: reproduction test
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Referenceopen allclose all
The injection of 0.1 mL Methanol into 5-day incubated eggs (n=5) resulted in 20% hatch.
A partial immersion of 5-day incubated eggs (n=5, 37°C) for 5 seconds resulted in 60% hatch, immersion for 10 seconds with 10 eggs at 20°C resulted in 50% hatch.
A partial immersion of unincubated eggs (n=9, room temp.) for 10 seconds resulted in 66%.
In none of the tests abnormal embryos were observed.
Description of key information
Key value for chemical safety assessment
Additional information
In water, sodium methanolate rapidly hydrolyses to methanol and sodium hydroxide (OECD, 2002). Due to the rapid hydrolysis of sodium methanolate, the assessment of the toxicity to birds is based on the products of hydrolysis i.e. methanol and sodium hydroxide.
No studies on the toxicity of sodium methanolate to birds are available. The relevant degradation products of sodium methanolate are of low mammalian toxicity (see IUCLID Section 7) and do not have the potential for bioaccumulation. Thus, there is no risk for secondary poisoning and testing of the toxicity to birds not required and waived.
According to ECHA Guidance document R.7c published by ECHA (2017) testing for avian toxicity is not required if a risk for secondary poisoning is negligible (e.g. if the substance is readily biodegradable, has a low potential for bioaccumulation and moreover there is no evidence of toxicity in mammalian repeat dose or reproduction tests). Regarding the results from mammalian studies for methanol, only low toxicity is indicated. In addition, the available aquatic toxicity data on methanol only indicate low toxicity to birds. Furthermore, methanol is readily biodegradable and the potential for bioaccumulation is assumed to be low based on the low log Pow. Thus, methanol has a negligible risk for secondary poisoning and there is no need to investigate further the effects on birds.
For the sake of completeness, the available study on the relevant degradation product methanol indicating a low level of toxicity to birds is presented. In this study, the effects of methanol on 5-day incubated Gallus gallus domesticus eggs were investigated. The injection of 0.1 mL methanol into 5-day incubated eggs (n=5) resulted in 20% hatch. A partial immersion of 5-day incubated eggs (n=5, 37 °C) for 5 seconds resulted in 60% hatch, immersion for 10 seconds with 10 eggs at 20 °C resulted in 50% hatch and a partial immersion of un-incubated eggs (n=9, room temp.) for 10 seconds resulted in 66%.
In conclusion, there is no need for additional testing of methanol on the toxicity to birds.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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