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EC number: 918-594-3 | CAS number: 7723-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well performed and reported non GLP study similar to current OECD 405.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: FDA 16 CFR 1500.42 91 26,142
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- study performed before GLP guidelines
Test material
- Reference substance name:
- phosphorus
- EC Number:
- 918-594-3
- Cas Number:
- 7723-14-0
- Molecular formula:
- (P)n (Phosphorus red modification)
- IUPAC Name:
- phosphorus
- Reference substance name:
- Phosphorus
- EC Number:
- 231-768-7
- EC Name:
- Phosphorus
- Cas Number:
- 7723-14-0
- IUPAC Name:
- phosphine
- Details on test material:
- - Name of test material (as cited in study report): oiled red phosphorus 8Albright and wilson, LDT. Lot LT 22 RED PHOSPHORUS)
- Substance type: element
- Physical state: solid / powder
- Analytical purity: > 94,6 % +- 1,20 %
- Impurities (identity and concentrations): < 0,0055 % +- 0,0020 % yellow phosphorus
- Composition of test material, percentage of components:approx. 94,6 % total phosphorus, 0,08 % +- 0,010 % mineral oil
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: B and H Rabbitry, Rockville, MD, USA
- Age at study initiation: 10 week old
- Housing: wired bottom cages
- Diet (e.g. ad libitum): Purina Rat Chow
- Water (e.g. ad libitum): Acified water (pH 2.5)
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 72° to 76°F
- Humidity (%): 39 to 54 percent relative humidity
- Photoperiod (hrs dark / hrs light): 12h dark / 12h with artificial illumination.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 100 mg of the dry material was applied
- Duration of treatment / exposure:
- 24 hour
- Observation period (in vivo):
- 1, 24, 48 and 72 hour
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): sterile isotonic saline solution
- Time after start of exposure: 24 hour
- 100 mg of the dry material was applied to the eye by pulling out the lower eyelid to form a cup.
Only one eye was treated, the other served as control.
Three animals were treated in the right eye, three animals were treated in the left eye.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: n.a.
- Remarks on result:
- other: not irritating
- Irritant / corrosive response data:
- not irritating
- Other effects:
- none
Any other information on results incl. tables
The Instillation of 100 mg of oiled red phosphorus into rabbit eyes did not produce any irritation or injury to the cornea or iris. The conjunctivae of all rabbits showed a slight redness 1 hour after treatment. In one rabbit, a slight redness was also apparent at 24 hours. Five of six rabbits treated with the test material showed slight swelling at t hour post-treatment which was not present at 24-hours posttreatment. From these results it was concluded that oiled RP was neither corrosive or irritating to the eye.
CONJUNCTIVAE IRRITATION STUDY OF OILED RED PHOSPHORUS IN RABBITS | ||||||||||
Redness |
Chemosis |
|||||||||
Rabbit | ||||||||||
Number | Hours | Day | Hours |
Day | ||||||
1 | 24 | 48 | 72 | 7 | 1 | 24 | 48 | 72 | 7 | |
2360D | <1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
2361D | <1 | <1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
2362D | <1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
2363D | <1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
2364D | <1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2365D | <1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The Instillation of 100 mg of oiled red phosphorus into rabbit eyes did not produce any irritation or injury.
- Executive summary:
The Instillation of 100 mg of oiled red phosphorus into rabbit eyes did not produce any irritation or injury to the cornea or iris. The conjunctivae of all rabbits showed a slight redness 1 hour after treatment. In one rabbit, a slight redness was also apparent at 24 hours. Five of six rabbits treated with the test material showed slight swelling at t hour post-treatment which was not present at 24-hours posttreatment. From these results it was concluded that oiled Red Phosphorus was neither corrosive nor irritating to the eye.
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