Registration Dossier
Registration Dossier
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EC number: 918-594-3 | CAS number: 7723-14-0
Endpoint summary
Administrative data
Description of key information
Oral:
- female rats, LD50: > 15,000 mg/kg bw
- male/female rats, LD50: > 10,000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 15 mg/kg bw
Additional information
Justification for classification or non-classification
Due to the findings described above (LD50 oral in rats > 15,000 mg/kg bw) Red Phosphorus has not to be classified as acute orally toxic.
It can reasonably be deduced that Red Phosphorus does not exert systemic toxic effects after dermal application and thus does not have to be classified, because Red Phosphorus did not cause lethal effects after administration of a single oral dose of up to 15,000 mg/kg bw in rats. Furthermore the substance does not have to be classified as skin irritating and it is unlikely that higher amounts than tested in the acute oral toxcity study will be systemically available via the intact skin barrier. Therefore, testing is not scientifically necessary.
Due to the explosive properties of Red Phosphorus, an inhalation study applying relevant dust concentrations is technically not feasible.
Furthermore, in accordance with Section 1.2 of REACH Annex XI, there is sufficient weight of evidence from several independent sources of information leading to the conclusion that Red Phosphorus does not exert systemic toxic effects after acute inhalation exposure and thus does not have to be classified, because
- the LD50value for acute oral toxicity of Red Phosphorus is >15,000 mg/kg bw,
- Red Phosphorus does not have to be classified as skin irritating,
- inhalation to consumer is very unlikely to occur, since the substance is embedded in polymeric matrices for application by the consumer. and
- occupational health surveillance data obtained from workers of the production site do not give any hint concerning adverse systemic effects and effects on the respiratory tract (for expert statement please refer to Chapter 7.10.1)
Therefore, it is concluded that testing of acute inhalation toxicity of Red Phosphorus is not scientifically necessary.
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