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Diss Factsheets
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EC number: 203-809-9 | CAS number: 110-86-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliable with restrictions; acceptable, well-documented publication/study report based on guidelines, which meets basic scientific principles.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Pyridine
- EC Number:
- 203-809-9
- EC Name:
- Pyridine
- Cas Number:
- 110-86-1
- Molecular formula:
- C5H5N
- IUPAC Name:
- pyridine
- Details on test material:
- 99% purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Details on inhalation exposure:
- Groups of six male rats, eight weeks old and weighing between 237 and 279 g, were exposed to the test substance via inhalation (nose only exposure) at concentrations of 1600, 4900 and 6000 ppm for a single four-hour period. Surviving rats were weighed and observed daily for 14 days post exposure, weekends excluded except when deemed necessary by the rats’ condition. Except during exposure, feed and water were available ad libitum. The atmospheric concentration of the test substance was determined by gas chromatography at approximately
30-minutes intervals throughout the exposure period. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gas chromatography
- Duration of exposure:
- 4 h
- Concentrations:
- 1600, 4900 and 6000 ppm
- No. of animals per sex per dose:
- 6 males per dose
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 4 900 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Lower value of 4900 ppm is selected, equivalent to 15852 mg/m3
- Mortality:
- Within 4 days, 2 of 6 rats which were dosed by nose at the 4900 ppm dose group were found dead. In the group dosed with 6000 ppm, 5 of 6 rats were found dead.
- Clinical signs:
- other: Red nasal discharge and lack of startle response when the exposure chamber was tapped. Rats from the low dose group had labored breathing, wet perineum, hunched posture, ruffled fur and red ocular discharge. Rats from the mid (4900 ppm) dose group were
- Body weight:
- Severe weight loss in all dose groups on one day after exposure.
Any other information on results incl. tables
During exposure, some rats in all groups had red nasal discharge and diminished or no response when the chamber was tapped. Immediately after the four-hour exposure to 1600 ppm, rats had slightly labored breathing, wet perineum, hunched posture, ruffled fur and slight red ocular discharge. Rats exposed to 4900 ppm were limp and prostrate and had very slow and shallow breathing. Within one hour, these rats began to show signs of movement and had severely labored breathing. At 6000 ppm, five rats died during exposure. During the post-exposure observation period, one rat exposed to 4900 ppm was found dead the morning after exposure; another four days post exposure. Surviving rats in all groups had slight to severe weight loss one day post exposure. At 4900 ppm, some rats continued to lose weight for three more days. No adverse clinical signs were observed in surviving rats exposed to 1600 and 6000 ppm during the recovery period. At 4900 ppm, rats had labored breathing, red nasal, ocular and oral discharge, no righting or grasping reflexes, discolored fur and tremors. All clinical signs were absent six days post exposure.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Pyridine was tested in a nose-only exposure protocol in a guideline acute inhalation test. The LC50 in male rats after 4 hours was 4900 ppm or 15852 mg/m3.
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