Pyridine

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This is a limited case series of human sensitisation events as reported by medical personnel in a journal expressly dedicated to case reports. Neither the hazard nor the risk of dermal sensitisation can be determined from this data.

Data source

Reference

Reference Type:

publication

Title:

Narrow spectrum of cross-sensitization with pyridine derivatives

Author:

Sasseville D, Kwong P and Yu K

Year:

1998

Bibliographic source:

Contact Dermatitis, 38: 212-214

Materials and methods

Type of sensitisation studied:

skin

Study type:

case report

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

This is an observational report of case series.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Pyridine

EC Number:

203-809-9

EC Name:

Pyridine

Cas Number:

110-86-1

Molecular formula:

C5H5N

IUPAC Name:

pyridine

Details on test material:

A large series of substances was tested, including: 2-aminopyridine, 2,6-diaminopyridine, 2,3-diaminopyridine, 3-pyridine carboxylic acid, 5-hydroxy-6-methyl-3,4-pyridinemethanol HCl, zinc bis(pyridinethiol-1-oxide), 2,6-diamino-3-phenylazopyridine, 2-[benzyl(2-dimethylaminoethyl)amino]pyridine, N'-2-pyridylsulfanilamide, 5-[p-(2-pyridylsulfamoyl)phenylazo]salicylic acid, pyrimidine, 2-aminopyrimidine, 2-sulfanilamidopyrimidine Ag, pyrazine, 2-aminopyrazine, and pyridazine.

Method

Type of population:

other: patients with dermatology problems

Ethical approval:

not specified

Subjects:

5 adults

Route of administration:

dermal

Details on study design:

These are the same patients who served as control subjects in the 1996 study of dermal sensitisation to the chemicals used by a chemist who experienced a severe dermal exposure episode. In the 1996 study, 4 of 5 control subjects were sensitised to one or more pyridine derivatives. To illuminate their cross-reaction spectrum, they underwent patch testing with an extended series of chemicals that included pyridine, pyridazine, pyrimidine and pyrazine compounds. Some of these substances were bought from Aldrich Chemical Company, while others were obtained from the pharmaceutical industry. Various dilutions were prepared and patch tests were conducted in the usual manner.

Results and discussion

Results of examinations:

No positive reaction was seen by any of the subjects.

Applicant's summary and conclusion

Conclusions:

In a case series of 5 subjects who previously demonstrated dermal sensitisation to pyridine compounds, all patch test results to additional pyridine derivatives were negative. It appears that the cross-sensitisation spectrum of pyridine derivatives is narrow.