Dihexyl adipate

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

no hazard identified

Marine water

Hazard assessment conclusion:

no hazard identified

STP

Hazard assessment conclusion:

no hazard identified

Sediment (freshwater)

Hazard assessment conclusion:

no hazard identified

Sediment (marine water)

Hazard assessment conclusion:

no hazard identified

Hazard for air

Air

Hazard assessment conclusion:

no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

PNEC soil

PNEC value:

0.865 mg/kg soil dw

Assessment factor:

1 000

Extrapolation method:

assessment factor

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:

no potential for bioaccumulation

Additional information

According to Article 13 of Regulation (EC) No. 1907/2006 "General Requirements for Generation of Information on Intrinsic Properties of substances", Information on intrinsic properties of substances may be generated by means other than tests e.g. from information from structurally related substances (grouping or read-across), provided that conditions set out in Annex XI are met.

Annex XI, "General rules for adaptation of this standard testing regime set out in Annexes VII to X” states that “substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or ‘category’ of substances. This avoids the need to test every substance for every endpoint”.

Since the group concept is applied to the category members of the PFAE linear, data will be generated from a representative category member to avoid unnecessary animal testing. Additionally, once the group concept is applied, substances will be classified and labelled on this basis.

Conclusion on classification

Classification related key information

Log Kow: 6.3 (ASTM E1147)

Water solubility: 2.6 mg/L (OECD 105)

Biodegradation: 71 % in 28 days (OECD 301B)

BCF: 28.7 L/kg (BCFBAF v3.01; Arnot-Gobas estimate) 

Aquatic acute toxicity:

For fish: LC50 (96h) no toxic effects up to the limit of water solubility (< 2.6 mg/L in aqua dest, OECD 203)

For algae: EC50 (72h) no toxic effects up to the limit of water solubility (< 2.6 mg/L in aqua dest, OECD 201)

For crustacea: EC50 (48h) no toxic effects up to the limit of water solubility (< 2.6 mg/L in aqua dest, OECD 202)

Aquatic chronic toxicity:

For fish: no data

For algae: no adverse effects up to the limit of water solubility (< 2.6 mg/L in aqua dest, OECD 201)

For crustacean: no data

Non-Classification justification according to CLP

Based on the data above, the acute aquatic toxicity L(E)C50 is above the limit of water solubility for fish, algae and aquatic invertebrates. Dihexyl adipate (CAS 110-33-8) does not need to be classified and labeled as acute aquatic hazard according to the 2nd ATP of the Regulation (EC) No.1272/2008 (CLP).

Dihexyl adipate (CAS 110 -33 -8) is considered to be rapidly degradable. Valid chronic toxicity data are available for algae, indicating no effects in the range of water solubility. Therefore, Dihexyl adipate (CAS 110-33-8) does not need to be classified and labeled as long-term aquatic hazard according to the 2nd ATP of the Regulation (EC) No.1272/2008 (CLP).

M-factor for chronic aquatic toxicity: -

Non-Classification justification according to DSD

Based on the data above, Dihexyl adipate (CAS 110-33-8) is rapidly degradable and is considered to have a low potential for accumulation. The acute aquatic toxicity L(E)C50 is above the limit of water solubility in water for fish and daphnia. Therefore, Dihexyl adipate (CAS 110-33-8) does not need to be classified and labeled as environmental hazard according to Directive 67/548/EEC.