Methyl 3-mercaptopropionate

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2005-02-24 to 2005-04-28

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study conducted according to OECD Guideline 102 (Melting point/Melting Range).

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2005

Report date:

2005

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Principles of method if other than guideline:

N/A

GLP compliance:

yes (incl. QA statement)

Remarks:

The Swiss GLP Monitoring Authorities

Type of method:

method to determine freezing temperature

Test material

Test material information

Constituent 1

Reference substance name:

Methyl 3-mercaptopropionate

EC Number:

220-912-4

EC Name:

Methyl 3-mercaptopropionate

Cas Number:

2935-90-2

Molecular formula:

C4H8O2S

IUPAC Name:

methyl 3-sulfanylpropanoate

Details on test material:

- Name of test material (as cited in study report): methyl 3-mercaptopropionate
- Molecular formula (if other than submission substance): N/A
- Molecular weight (if other than submission substance): N/A
- Smiles notation (if other than submission substance): N/A
- InChl (if other than submission substance): N/A
- Structural formula attached as image file (if other than submission substance): N/A
- Substance type: active
- Physical state: liquid
- Stability under test conditions: N/A
- Storage condition of test material: in the refrigerator at about 4 degrees C
- Other: N/A

Results and discussion

Melting / freezing point

Melting / freezing pt.:

< -69 °C

Any other information on results incl. tables

A preliminary test was performed to check the approximate freezing temperature of 3 - mercaptopropanoic acid methyl ester (MMP). The test item was stored at -18 degrees C in a deep freezer. As the sample was not frozen after storage for 22 hours, the freezing temperature of 3 -mercaptopropanoic acid methyl ester (MMP) is below -18 degrees C.

The determination of the freezing temperature with thermocouples showed no heat effect from which freezing can be deduced. Therefore, the phase transformation was determined visually.

During the tests, 7 mL of the test item placed in a small test tube were cooled down from room temperature to about -70 degrees C using a dry ice and acetone mixture. Until -60 degrees C, the appearance of the test item was unchanged. At -64 degrees C, the test item becomes turbid. At -69 degrees C, the test item was more viscous, but still movable.

Applicant's summary and conclusion

Conclusions:

The test item did not freeze under the conditions of the test. The freezing point of the test item is below -69 deg. C (204.15 K).

Executive summary:

N/A