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EC number: 251-882-0 | CAS number: 34206-40-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue MAC3 component of the reaction mass Wasox-MMAC2, has a molecular structure similar tobutan-2-one O,O',O'',O'''-silanetetrayltetraoxime and therefore, they also have comparable values for the relevant molecular properties for abiotic degradation.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 499.18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (analogue substance)
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: (Based on read-across approach on an analogue)
- Details on results:
- Based on the experimental results on analogue substance Wasox-MMAC2 (EC50-3h > 300 mg/L for activated sludge of a predominantly domestic sewage), the read-across approach was applied and the EC50 (3h) for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be > 499.18 mg/L.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on read-across approach from experimental data on analogue Wasox-VMAC2, the 3h-EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be > 499.18 mg/L.
- Executive summary:
An Activated Sludge, Respiration Inhibition Test was performed on analogue Wasox-MMAC2 according to the OECD Guideline 209 using activated sludge from a sewage treatment plant treating predominantly domestic sewage. The 3h-EC50 was determined to be > 300 mg/L, basis for effect: respiration rate. Based on these results, the read-across approach was applied and the 3h-EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be > 499.18 mg/L.
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The target substance TOS is an oxime silane that undergoes rapid hydrolysis in aqueous to MEKO and the corresponding silanol. At the same time, silanols undergo continuous condensation reaction to produce higher molecular weight siloxanes which are in the molecular weight range large enough to be considered biologically unavailable. Therefore, the toxicity of TOS is due to the hydrolysis product MEKO and their values are comparable.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 5 min
- Dose descriptor:
- other: EC50
- Effect conc.:
- 1 020.94 mg/L
- Remarks on result:
- other: (Based on read-across approach from an analogue)
- Details on results:
- Based on the experimental results obtained with the analogue substance butanone oxime (5min EC50 =630 mg/L, Photobacterium phosphoreum), the read-across approach is applied and the 5 min EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be 1020.94 mg/L.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on the read-across approach form experimental results on analogue butanone oxime, the 5 min-EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime in Photobacterium phosphoreum was determined to be 1020.94 mg/L.
- Executive summary:
Based on the experimental results on analogue substance butanone oxime where the 5 min-EC50 for Photobacterium phosphoreum was determined to be 955 mg/L, the read-across approach was applied and the 5 min-EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be 1020.94 mg/L.
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue methyltriacetoxysilane has a molecular structure similar to butan-2-one O,O',O'',O'''-silanetetrayltetraoxime and therefore, they also have comparable values for the relevant molecular properties for toxicity to microorganisms.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 169.14 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (analogue substance)
- Basis for effect:
- other: Biodegradation
- Remarks on result:
- other: (Based on read-across approach from an analogue)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on the experimental results on analogue substance methyltriacetoxysilane, the read-across approach was applied and NOEC (28 d) for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be 169.14 mg/L.
- Executive summary:
A ready biodegradability manometic respirometry test was performed according to OECD Guideline 301 F on analogue methyltriacetoxysilane and 28 day-NOEC was determined to be 100 mg/L since the substance was readily biodegradable (79.5% of biodegradation at 28 days) and did not inhibit the degradation of the toxicity test (83.9% of biodegradation after 28 days) up to 100 mg/L under aerobic conditions. Based on this results, the read-across approach was applied and 28 day-NOEC for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be 169.14 mg/L under test conditions.
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The target substance TOS is an oxime silane that undergoes rapid hydrolysis in aqueous to MEKO and the corresponding silanol. At the same time, silanols undergo continuous condensation reaction to produce higher molecular weight siloxanes which are in the molecular weight range large enough to be considered biologically unavailable. Therefore, the toxicity of TOS is due to the hydrolysis product MEKO and their values are comparable.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Dose descriptor:
- other: Toxicity
- Effect conc.:
- >= 673.5 mg/L
- Remarks on result:
- other: (Based on read-across approach from an analogue)
- Details on results:
- Based on the experimental results obtained with the analogue substance butanone oxime (toxicity =630 mg/L, Pseudomonas sp. ), the read-across approach is applied and the toxicity to microorganisms for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be 673.5 mg/L.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on the read-across approach from analogue substance butanone oxime, butan-2-one O,O',O'',O'''-silanetetrayltetraoxime
was determined to be toxic to Pseudomonas sp. at 673.50 mg/L. - Executive summary:
Based on the read-across approach from analogue substance butanone oxime, butan-2-one O,O',O'',O'''-silanetetrayltetraoxime
was determined to be toxic to Pseudomonas sp. at 673.50 mg/L.
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue VAC3 component of the reaction mass Wasox-VMAC2, has a molecular structure similar to butan-2-one O,O',O'',O'''-silanetetrayltetraoxime and therefore, they also have comparable values for the relevant molecular properties for abiotic degradation.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 482.51 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- (analogue substance)
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: (Based on read-across approach from an analogue)
- Details on results:
- Based on the experimental results on analogue substance Wasox-VMAC2 (EC50-3h > 300 mg/L) for activated sludge of a predominantly domestic sewage), the read-across approach was applied and the EC50 (3h) for EAC3 was calculated to be > 482.51 mg/L.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on read-across approach from experimental data on analogue Wasox-VMAC2, the 3h-EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be > 482.51 mg/L.
- Executive summary:
An Activated Sludge, Respiration Inhibition Test was performed on analogue Wasox-VMAC2 according to the OECD Guideline 209 using activated sludge from a sewage treatment plant treating predominantly domestic sewage. The 3h-EC50 was determined to be > 300 mg/L, basis for effect: respiration rate. Based on these results, the read-across approach was applied and the 3h-EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be > 482.51 mg/L.
Referenceopen allclose all
Description of key information
Weight of evidence: Read-across from experimental results on butanone oxime: butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be toxic to Pseudomonas sp.at 673.50 mg/L.
Weight of evidence: Read-across from experimental results on butanone oxime the 5 min-EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be 1020.94 mg/L.
Weight of evidence: Read-across from experimental results on methyltriacetoxysilane: The 28 day-NOEC for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be 169.14 mg/L under test conditions.
Weight of evidence: Read-across from experimental results on Wasox-VMAC2: the 3h-EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be > 482.51 mg/L.
Weight of evidence: Read-across from experimental results on Wasox-MMAC2: the 3h-EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be > 499.18 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 482.51 mg/L
- EC10 or NOEC for microorganisms:
- 169.14 mg/L
Additional information
The toxicity to microorganism is analized by the read-across approach from analogue substances:
- Read-across from experimental results on butanone oxime: By the read-across from butanone oxime, the toxicity to microorganism of the hydrolysis product of the test item is analysed and covered.
- Read-across from experimental results on analogue silanes: By the read-across from analogue silanes (methyltriacetoxysilane, Wasox-VMAC2 and Wasox-MMAC2), the toxicity to microorganism of the silane part of the substance is analysed and covered, since both test item butan-2-one O,O',O'',O'''-silanetetrayltetraoxime, like methyltriacetoxysilane, Wasox-VMAC2 and Wasox-MMAC2, undergo rapid hydrolsyis in aqueous to corresponding silanols and at the same time, these silanols undergo continuous condensation reactions.
Read-across from experimental results on butanone oxime:
Weight of evidence: Based on the read-across approach from analogue substance butanone oxime, butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be toxic to Pseudomonas sp.at 673.50 mg/L.
Weight of evidence: Based on the experimental results on analogue substance butanone oxime where the 5 min-EC50 for Photobacterium phosphoreum was determined to be 955 mg/L, the read-across approach was applied and the 5 min-EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be 1020.94 mg/L.
Read-across from experimental results on analogue silanes:
Weight of evidence: Based on the experimental results obtained in a ready biodegradability test (OECD 301F) performed on analogue methyltriacetoxysilane (28 day-NOEC = 100 mg/L), the read-across approach was applied and the 28 day-NOEC for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be 169.14 mg/L under test conditions.
Weight of evidence: Based on the experimental results obtained in an Activated Sludge, Respiration Inhibition Test (OECD 209) performed on analogue Wasox-VMAC2 (3h-EC50 > 300 mg/L, basis for effect: respiration rate), the read-across approach was applied and the 3h-EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be > 482.51 mg/L.
Weight of evidence: Based on the experimental results obtained in an Activated Sludge, Respiration Inhibition Test (OECD 209) performed on analogue Wasox-MMAC2 (3h-EC50 > 300 mg/L, basis for effect: respiration rate), the read-across approach was applied and the 3h-EC50 for butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was calculated to be > 499.18 mg/L.
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