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EC number: 204-559-3 | CAS number: 122-63-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- A maximization test was carried out with 4% (2760 µg/cm2) benzyl propionate in petrolatum on 25 healthy male patients
- GLP compliance:
- not specified
- Type of study:
- other: maximization test
- Species:
- human
- Strain:
- not specified
- Sex:
- male
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 4% = 2760 µg/cm2
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 4% = 2760 µg/cm2
- No. of animals per dose:
- 25 males
- Details on study design:
- Application was under occlusion to the same site on the forearms of all subjects for five alternate day, 48 h periods. The patch sites were pretreated for 24 h with 5% aqueous sodium lauryl sulfate (SLS) under occlusion. Following a 10 day rest period, challenge patches were applied to fresh sites on the back for 48 h under occlusion. The challenge site was pretreated for 1 h with 10% SLS. The challenge site was evaluated at 48 and 72 h
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 4% (2760 µg/cm2)
- No. with + reactions:
- 0
- Total no. in group:
- 25
- Clinical observations:
- No sensitization reactions on evaluation of the challenge site at 48 and 72 hrs
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 1st reading. . Hours after challenge: 48.0. Group: test group. Dose level: 4% (2760 µg/cm2) . No with. + reactions: 0.0. Total no. in groups: 25.0. Clinical observations: No sensitization reactions on evaluation of the challenge site at 48 and 72 hrs .
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Maximization test was carried out with 4% (2760 µg/cm2) benzyl propionate in petrolatum on 25 healthy males. On evaluation of the challenge site at 48 and 72 hrs no sensitization reactions were observed. Thus suggesting that benzyl propionate was non sensitizing to skin in humans.
- Executive summary:
Maximization test was carried out with 4% (2760 µg/cm2) benzyl propionate in petrolatum on 25 healthy males. On evaluation of the challenge site at 48 and 72 hrs no sensitization reactions were observed. Thus suggesting that benzyl propionate was non sensitizing to skin in humans.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Results of the Supporting studies:
In the Maximization test on healthy males no sensitization reactions were observed, also no allergic reaction were reported in a closed patch test with 38 patients with contact dermatitis, and no positive response reported in the Open Epicutaneous Test in the guinea pigs.
Migrated from Short description of key information:
The substance, benzyl propionate is found to be non sensitising to human males in a Maximization test.
Justification for selection of skin sensitisation endpoint:
Data is from a reliable data source from publication journal of Food and Chemical Toxicology
Justification for classification or non-classification
The available studies indicate that the test substance, benzyl propionate is non sensitising to skin and hence is being classified as 'Non sensitising' as per the CLP classification.
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