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Diss Factsheets
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EC number: 309-913-1 | CAS number: 101357-16-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Internationally accepted method, EPI-Suite EPA (USA)
- Principles of method if other than guideline:
- EPI-Suite WSKOW v1.43
- Type of method:
- other: estimated by calculation
- Key result
- Water solubility:
- 0 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: Water solubility EPISUITE = 4.03E-008 mg/L at 25 ºC (WSKOW v1.43) log Kow used: 9.78 (estimated)
- Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
Water solubility EPISUITE = 4.03E-008 mg/L at 25 ºC (WSKOW v1.43)
log Kow used: 9.78 (estimated) - Executive summary:
Water solubility EPISUITE = 4.03E-008 mg/L at 25 ºC (WSKOW v1.43)
log Kow used: 9.78 (estimated)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline and EU method. GLP study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 8 other: g C/L
- Temp.:
- 20 °C
- pH:
- ca. 4
- Remarks on result:
- other: Measured TOC: 8 g C/L
- Key result
- Water solubility:
- 1.6 other: g C/L
- Temp.:
- 20 °C
- pH:
- ca. 7
- Remarks on result:
- other: Measured TOC: 1.6 g C/L
- Key result
- Water solubility:
- 2 other: mg C/L
- Temp.:
- 20 °C
- pH:
- ca. 10
- Remarks on result:
- other: Measured TOC: 2 mg C/L
- Details on results:
- The measured water solubility (as TOC value) of the test item strongly depends on the pH values. At 20 ºC , depending on the pH value the solubility equals as follows:
at pH about 4 the TOC is equal to about 8.0 g C/l
at pH about 7 the TOC is equal to about 1.6 g C/l
at pH about 10 the TOC is equal to about 2 mg C/l - Conclusions:
- Interpretation of results: The test item principal constituents are of low water solubility, but one or more of minority of constituents is an acid compound of slightly better water solubility.
For each of the pH tested, as the loading increases the TOC value decreases what may be a result of decreasing pH values. Probably, the test item contains an acidic compound(s) which dissolving in buffers lowers the pH value of the test solutions. The TOC values strongly depends on the pH values.
It is expected that the test item principal constituents are of low water solubility, but one or more of minority of constituents is an acid compound of slightly better water solubility. - Executive summary:
The water solubility determination of the test substance was carried out using the shake flask method according to OECD guideline 105 an EU method A.6. Five loading rates were chosen to study the effect of loading rate on the measured water solubility of the test item. All the components were analysed using a non-discriminating method (TOC) in order to quantify the total amount of test item solubilized. The pH and the TOC values of the solutions obtained, by centrifugal separation from these suspensions, were measured. For each of the pH tested, as the loading increases the TOC value decreases what may be a result of decreasing pH values. Probably, the test item contains an acidic compound(s) which dissolving in buffers lowers the pH value of the test solutions. The TOC values strongly depends on the pH values. It is expected that the test item principal constituents are of low water solubility, but one or more of minority of constituents is an acid compound of slightly better water solubility.
Referenceopen allclose all
Estimated by calculation. No data provided on the temperature.
For each of the pH tested, as the loading increases the TOC value decreases what may be a result of decreasing pH values. Probably, the test item contains an acidic compound(s) which dissolving in buffers lowers the pH value of the test solutions. The TOC values strongly depends on the pH values. It is expected that the test item principal constituents are of low water solubility, but one or more of minority of constituents is an acid compound of slightly better water solubility.
Description of key information
Key study: OECD guideline and EU method. GLP study.
For each of the pH tested, as the loading increases the TOC value decreases what may be a result of decreasing pH values. Probably, the test item contains an acidic compound(s) which dissolving in buffers lowers the pH value of the test solutions. The TOC values strongly depends on the pH values. It is expected that the test item principal constituents are of low water solubility, but one or more of minority of constituents is an acid compound of slightly better water solubility.
Estimated value for the main component of the substance:
Water solubility EPISUITE = 4.03E-008 mg/L at 25 ºC (WSKOW v1.43)
log Kow used: 9.78 (estimated)
Key value for chemical safety assessment
- Water solubility:
- 0 mg/L
- at the temperature of:
- 25 °C
Additional information
Key study: OECD guideline and EU method. GLP study.
For each of the pH tested, as the loading increases the TOC value decreases what may be a result of decreasing pH values. Probably, the test item contains an acidic compound(s) which dissolving in buffers lowers the pH value of the test solutions. The TOC values strongly depends on the pH values. It is expected that the test item principal constituents are of low water solubility, but one or more of minority of constituents is an acid compound of slightly better water solubility.
Main component 1: Water solubility EPISUITE = 4.03E-008 mg/L at 25 ºC (WSKOW v1.43)
log Kow used: 9.78 (estimated)
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