Registration Dossier
Registration Dossier
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EC number: 230-029-6 | CAS number: 6920-22-5
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The test results of 1,2-octanediol (CAS 1117-86-8),the 72-hour LOEC and the EC50 were higher than 100 mg/L based on the growth rate. As 1,2-Hexanediol (CAS 6920-22-5) has similar properties and structurally differs only by a shorter carbon chain length (2 C-atoms less), the results obtained (EC50 and NOEC values) can be considered adequate for 1,2-hexanediol too.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 100 mg/L
Additional information
No experimental data with 1,2-Hexanediol are available. Therefore read-across to the structurally similar 1,2-Octanediol (see read-across justification) was conducted.
The available algae test with 1,2-Octanediol was performed with the freshwater green algal species Pseudokirchneriella subcapitata according to the OECD Guideline 201 (2006), and the Commission Regulation (EC) No 761/2009, C.3 in a 72 -hour static test under GLP conditions. The nominal concentrations of the test item of 1, 3.2, 10, 32 and 100 mg/L were tested in parallel with a control. The test item had no statistically significant inhibitory effect on the growth of the algae (average growth rate and yield) during the test period of 72 hours up to and including the highest nominal test concentration of 100 mg/L. The biological results were based on nominal concentrations as the test item was found to be stable during the test duration. The results of the study are: ErC50(72h) > 100 mg/L; EyC50(72h )> 100 mg/L; NOEC (growth rate & yield; 72h) >= 100 mg/L.
Furthermore data for the structurally similar 1,2-Pentanediol (CAS 5343-92-0) are available in the ECHA Registered substances database. The algae test with 1,2-Pentanediol resulted in an ErC50(72h) of 9334.7 mg/L and an ErC10 of 5477.3 mg/L.
Based on the test results of 1,2–Octanediol (CAS 1117-86-8) and the information from 1,2-Pentanediol (CAS 5343-92-0) it can be assumed, that 1,2-Hexanediol (CAS 6920-22-5) will show no statistically significant inhibitory effect on the growth of the algae during a 72h test period up to and including a nominal test concentration of 100 mg/L. Thus, an ErC50(72h) > 100 mg/L and a NOEC(growth rate) of >= 100 mg/L is used for the 1,2-Hexanediol safety assessment.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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