2-nitrophenol

Repeated dose toxicity: oral

Administrative data

Endpoint:

short-term repeated dose toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Secondary source

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Classification and Labelling of Dangerous Substances. Recommended form to be used by the Working group on the Classification and Labelling of Dangerous Substances in order to update Annex I of Directive 67/548/EEC.

Author:

Anonymous

Year:

1993

Bibliographic source:

Commission of the European Communities DG XI

Report date:

1993

Reference 2

Reference Type:

secondary source

Title:

Mononitrophenols

Author:

International Programme on Chemical Safety (IPCS)

Year:

2000

Bibliographic source:

http://www.inchem.org/documents/cicads/cicads/cicad_20.htm (query result from 2011-10-14)

Reference 3

Reference Type:

study report

Title:

Unnamed

Year:

1981

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)

Deviations:

not specified

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-nitrophenol

EC Number:

201-857-5

EC Name:

2-nitrophenol

Cas Number:

88-75-5

Molecular formula:

C6H5NO3

IUPAC Name:

2-nitrophenol

Details on test material:

- Name of test material (as cited in study report): o-Nitrophenol, 2-Nitrophenol
- Physical state: Solid
- Analytical purity: 99.6 %
- Impurities (identity and concentrations): ~ 0.3 % p-Nitrophenol

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

no data

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

28 days

Frequency of treatment:

no data

Doses / concentrations

Remarks:

Doses / Concentrations:
22, 67, and 200 mg/kg bw
Basis:
no data

No. of animals per sex per dose:

5

Control animals:

yes

Details on study design:

- Dose selection rationale: No higher doses were administered since the authors wanted to avoid crystallisation of the test substance in the stomach.

Examinations

Observations and examinations performed and frequency:

no data

Sacrifice and pathology:

no data

Other examinations:

no data

Results and discussion

Results of examinations

Details on results:

In all groups some animals showed unspecific symptoms which were not stated as in the study protocol significant.
Food intake decreased in high-dose males and in mid- and high-dose females, and final body weight decreased non-significantly in all dosed animals.
The absolute liver and kidney weights were decreased in mid-dose animals, and the relative testes weight increased in low- and mid-dose males and decreased in high-dose males. In all dosed animals, the relative and absolute weights of the adrenal glands increased.
The haematological examination, clinical chemistry, and histopathological examination of the major organs and tissues did not give any indication of a substance-related toxic effect in comparison with controls.

Effect levels

Dose descriptor:

NOAEL

Effect level:

>= 200 other: mg/kg bw (not further specified)

Sex:

male/female

Basis for effect level:

other: see 'Remark'

Target system / organ toxicity

Critical effects observed:

not specified