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Diss Factsheets
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EC number: 201-857-5 | CAS number: 88-75-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Studies in Detoxication 39. Nitro Compounds.
- Author:
- Robinson D, Smith JN, Williams RT
- Year:
- 1 951
- Bibliographic source:
- Biochem J 50, 221-227
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Rhone-Poulnec Chimie Courbevoie Cedex
- Year:
- 1 977
- Bibliographic source:
- IUCLID Chemical Data Sheet, edited 2000-02-19
- Reference Type:
- secondary source
- Title:
- Toxicological Profile for Nitrophenols: 2-Nitrophenol, 4-Nitrophenol
- Author:
- ATSDR
- Year:
- 1 992
- Bibliographic source:
- U.S. Department of Health and Human Services, Public Health Service.
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- The metabolism of the purified test substance was analysed in rabbits after gavage of a suspension in water. Metabolite analysis was carried out after isolation from the 24h urine.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-nitrophenol
- EC Number:
- 201-857-5
- EC Name:
- 2-nitrophenol
- Cas Number:
- 88-75-5
- Molecular formula:
- C6H5NO3
- IUPAC Name:
- 2-nitrophenol
- Details on test material:
- - Name of test material (as cited in study report): o-Nitrophenol
- Physical state: Solid
- Analytical purity: The commercial product was purified by recrystallisation from ligroin or aqueous ethanol
- m.p. 45 °C
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- no data
- Duration and frequency of treatment / exposure:
- Single administration
Doses / concentrations
- Remarks:
- Doses / Concentrations:
- For the determination of the excreted free or conjugated test substance: 200 mg/kg bw (3 animals), and 450 mg/kg bw (1 animal)
- For the determination of the excreted amino derivates of the test substance: 330 mg/kg bw (3 animals)
- For the determination of the excreted glucuronic acid and ethereal sulphate conjugations of the test substance: 200 mg/kg bw (3 animals)
- No. of animals per sex per dose / concentration:
- 3 rabbits per dose (not further specified)
- Control animals:
- not specified
- Details on study design:
- Rabbits were treated with an aqueous suspension of the test material via gavage. 24 h urine was sampled and analysed for free and conjugated test substance, as well as for the reduction of the nitro group and the oxidation of the test substance. Furthermore, ß-glucuronides and ethereal sulphates of the test substance have been isolated from the urine and quantitatively analysed.
Results and discussion
Main ADME resultsopen allclose all
- Type:
- metabolism
- Results:
- nitrophenylglucuronides (70 %), ethereal sulphates (10 %), reduced nitro group (6 %), nitroquinol (< 1 %)
- Type:
- excretion
- Results:
- renal pathway (80-90 % within 24 hours)
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- At least 80-90 % of the test substance was excreted within 24 hours. The test substance was excreted in conjugated forms, there being only small amounts (<1 %) of the unchanged free phenol excreted. The main metabolites were the nitrophenylglucuronides which account for about 70 % of the dose. The corresponding ethereal sulphates were also excreted (about 10 %). The nitro group of the test substance underwent reduction in vivo only to a minor extent, and most of it was excreted unchanged. The extent of reduction was about 6 %. The test substance also underwent oxidation to a very small extent (<1 %) and yielded traces of nitroquinol. The dihydric phenol produced was similar to those formed during the Elbs persulphate oxidation of the test substance. There was a significance of the similarity in relation to free radicals. The ß-glucuronides of the test substance were isolated and characterised as triacetyl ß-o-nitrophenyl-D-glucuronide and its methyl ester.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.