Registration Dossier
Registration Dossier
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EC number: 270-147-5 | CAS number: 68411-76-7 The residuum from the distillation of the products from the air oxidation of cyclohexane. It consists of alcohols, acids and lactones having carbon numbers predominantly in the range of C4 through C6.
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- 10 male albino guinea pigs were exposed to 25% and 2.5% of test substance in propylene glycol on the shaved intact shoulder skin. Irratation was observed after 24 and 48 h. To test for sensitisation, a series of sacral intradermal injections was given with 0.1 ml of 1% test substance in dimethyl phthalate. Following a 2 week rest period, the animals were chaleenged by rubbing 1 drop (ca 0.05 ml) of 25% and a 2.5% solution of the test substance on the intact shaven shoulder skin. A group of 10 previously unexposed guinea pigs of similar age received similar applications.
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Cyclohexane, oxidized, non-volatile residue
- EC Number:
- 270-147-5
- EC Name:
- Cyclohexane, oxidized, non-volatile residue
- Cas Number:
- 68411-76-7
- Molecular formula:
- contains many components
- IUPAC Name:
- 5-hydroxypentanoic acid; 6-hydroxyhexanoic acid; hexanedioic acid; oxolan-2-one; pentanoic acid
- Reference substance name:
- Cyclohexane oxidized, non-volatile residue
- IUPAC Name:
- Cyclohexane oxidized, non-volatile residue
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: albino
- Sex:
- male
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- propylene glycol
- Concentration / amount:
- 25 and 2.5%. Intradermal injections were done with 1% test substance in dimethyl terephthalate
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- propylene glycol
- Concentration / amount:
- 25 and 2.5%. Intradermal injections were done with 1% test substance in dimethyl terephthalate
- No. of animals per dose:
- 10
- Challenge controls:
- 10
- Positive control substance(s):
- no
Results and discussion
Any other information on results incl. tables
The test substance solution of 25% was slightly irritating to the skin of 7 of the 10 animals after 24 h. Therefore the challenge results could only be observed with the 2.5% solution. No effects were observed in all 10 animals.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Executive summary:
not sensitizing for skin
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