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Diss Factsheets
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EC number: 939-719-8 | CAS number: 5502-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Summer 1978.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Study appeared to follow OECD 405 with the following deviations: age of the animals not reported; eyes were not examined 24 hours pre-treatment; uncertain whether test material was placed in the conjunctival sac of the eye.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- age of the animals not reported; eyes were not examined 24 hours pre-treatment; uncertain whether test material was placed in the conjunctival sac of the eye.
- Principles of method if other than guideline:
- The Draize irritation procedure was applied.:
J.H. Draize, “Dermal toxicity”, in Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, publ., The Association of Food and Drug Officials of the United States, 1959, p. 51.
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP
Test material
- Reference substance name:
- cis-4-(isopropyl)cyclohexanemethanol
- EC Number:
- 237-539-8
- EC Name:
- cis-4-(isopropyl)cyclohexanemethanol
- Cas Number:
- 13828-37-0
- Molecular formula:
- C10H20O
- IUPAC Name:
- cis-(4-propan-2-ylcyclohexyl)methanol
- Reference substance name:
- trans-(4-propan-2-ylcyclohexyl)methanol
- Cas Number:
- 13674-19-6
- Molecular formula:
- C10H20O
- IUPAC Name:
- trans-(4-propan-2-ylcyclohexyl)methanol
- Test material form:
- not specified
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The untreated left eye served as the control.
- Amount / concentration applied:
- Instillation of 0.1 gram of the test material.
- Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- All eyes were examined 24, 48, and 72 hours and at four, six, seven, and eight days after dosing.
- Number of animals or in vitro replicates:
- 6 per group
- Details on study design:
- no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 96 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #2 & #4
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #3 & #6
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0.6
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, #4 & #5
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal: #2, #3 & #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, #2, #3, #4, #5 & #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal: #1, #2, #3, #4, #5 & #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Other effects:
- no data
Any other information on results incl. tables
Table 7.3.2/1: Irritant/corrosive response data each animal at each observation time up to removal from the test
Score at time point / Reversibility | Cornea | Iris (/2) | Conjunctivae | ||
Opacity (/4) | Redness (/3) | Chemosis (/4) | Discharge (/3) | ||
24 h | 0 / 0 / 0 / 0 / 0 / 0 | 0 / 0 / 0 / 0 / 0 / 0 | 2 / 2 / 1 / 2 / 1 / 1 | 1 / 0 / 0 / 1 / 1 / 0 | 2 / 0 / 1 / 1 / 2 / 0 |
48 h | 0 / 0 / 0 / 0 / 0 / 0 | 0 / 0 / 0 / 0 / 0 / 0 | 1 / 1 / 0 / 1 / 1 / 0 | 0 / 0 / 0 / 0 / 0 / 0 | 1 / 0 / 0 / 0 / 1 / 0 |
72 h | 0 / 0 / 0 / 0 / 0 / 0 | 0 / 0 / 0 / 0 / 0 / 0 | 1 / 0 / 0 / 0 / 0 / 0 | 0 / 0 / 0 / 0 / 0 / 0 | 0 / 0 / 0 / 0 / 0 / 0 |
96 / 120 / 144h | 0 / 0 / 0 / 0 / 0 / 0 | 0 / 0 / 0 / 0 / 0 / 0 | 0 / 0 / 0 / 0 / 0 / 0 | 0 / 0 / 0 / 0 / 0 / 0 | 0 / 0 / 0 / 0 / 0 / 0 |
Average 24h, 48h, 72h | 0.0 / 0.0 / 0.0 / 0.0 / 0.0 / 0.0 | 0.0 / 0.0 / 0.0 / 0.0 / 0.0 / 0.0 | 1.33 / 1.0 / 0.33 / 1.0 / 0.67 / 0.33 | 0.33 / 0.0 / 0.0 / 0.33 / 0.33 / 0.0 | 1.0 / 0.0 / 0.33 / 0.33 / 1.0 / 0.0 |
Reversibility*) | - | - | c. | c. | c. |
Average time for reversion | - | - | 72 h | 48 h | 72 h |
*) Reversibility: c. = completely reversible; n.c. = not completely reversible; n. = not reversible
E = scoring masked
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material caused slight eye irritation; however, these effects were not noted by 96 hours post-application. The mean scores of conjunctival redness and conjunctival oedema were below 2 in all animals following grading at 24, 48 and 72 hours after installation of the test material.
- Executive summary:
The test material caused slight eye irritation; however, these effects subsided and were not noted in any animal by 96 hours post-application. The mean scores of conjunctival redness and conjunctival oedema were below 2 in all animals following grading at 24, 48 and 72 hours after installation of the test material. Based on the data, the substance was considered to be a slight primary irritant to the eye of the rabbit.
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