Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 201-159-0 | CAS number: 78-93-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Acute oral toxicity:
According to the data provided in the REACH dossier of butanone, dissiminated on the ECHA homepage, butanone is considered to be of low toxicity after single ingestion.
Rat oral: LD50 = 4.29 ml/kg bw
Rat oral: LD50 = 2193 mg/kg bw (read across secondary butyl alcohol).
Further data from secondary sources (MAK documentation of the Deutsche Forschungsgemeinschaft-DFG); OECD SIDS) reported oral LD50 values in mice and rats between 2000 and 6000 mg/kg bw.
Acute inhalation toxicity:
In an inhalation hazard test Sprague Dawley rats were exposed to an atmosphere that had been saturated with the volatile parts of butanone (vapour) at 20°C (BASF 1980). Nominal test substance concentrations ranged between 220 and 330 mg/l (not verified analytically). After 10 minutes exposure 0/12 animals died. Mortality was observed after 30 minutes, 1 hour and 1.2 hour exposure (2/18, 1/6, 3/6 animals respectively). Evidences for irritative effects on the respiratory system and narcotic effects have been observed.
Data from secondary source (OECD SIDS) reported inhalation LC50 values in rats to be greater than 5000 ppm (>15 mg/l). Overall butanone is considered to be of low toxicity after acute inhalation.
Acute dermal toxicity:
According to the data provided in the REACH dossier of butanone, dissiminated on the ECHA homepage, butanone is considered to be virtually non toxic after single skin contact.
Rabbit dermal: LD50 > 10 ml/kg bw
Further data from secondary source (OECD SIDS) reported dermal LD50 values in rabbits from 6.4 to 8 g/kg bw.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.