Registration Dossier
Registration Dossier
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EC number: 617-903-6 | CAS number: 86675-46-9
Endpoint summary
Administrative data
Description of key information
The test substance was found to be not irritating or corrosive to the skin and only slightly irritating to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
In a GLP compliant skin irritation study, performed according to OECD guideline 404, 0.5mL of the test substance was applied occlusive on the shaved skin of three male New Zealand White rabbits for 4 hours (Duphar B.V. 1986). Observation were made at 30-60 minutes, and at 24, 48, and 72 hours after patch removal. There was neither erythema nor oedema at any of the readings and therefore Polyol Ixol M125 is considered not to be irritant to the skin.
Eye irritation:
In a GLP compliant eye irritation study, performed according to OECD guideline 405, 0.1mL of the test substance was placed in the conjunctival sac of one eye of three New Zealand White rabbits (Duphar 1986). The eyes were examined for 7 days. The conjuctiva was slightly irritated in all rabbits one hour after treatment. The palpebral conjunctiva of two rabbits was also slightly damaged from one hour till 72 hours after application. The cornea of one rabbit was slightly irritated from 24 hours till 72 hours after treatment. The irritation had disappeared in one rabbit at 24 hours, in the second at 72 hours and in the third at 7 days after treatment. Based on these observations, Polyol IXOL M125 is considered to be a slight irritant to the eye.
Justification for classification or non-classification
Based on the findings in the skin and eye irritation study the test substance does not need to be classified according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008
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