Registration Dossier
Registration Dossier
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EC number: 271-689-5 | CAS number: 68604-38-6
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (14 d) ≥ 20 mg/L (Toxicity control of ready biodegradation test OECD 301B)
Key value for chemical safety assessment
Additional information
Studies on the toxicity of Fatty acids, C16-18 and C18-unsatd.,
hexaesters with dipentaerythritol (CAS 68604-38-6) to aquatic
microorganisms are not available. Therefore the assessment of the
toxicity to microorganisms is based on the NOEC determined in the
toxicity control reported in the study on ready biodegradability. This
approach is suitable for substances with high degrading rates or no
degradation inhibition in the positive control in ready biodegradability
tests. This is in accordance with the Guidance on information
requirements and chemical safety assessment (Chapter R.7b: Endpoint
specific guidance, ECHA 2012).
A substance can be assumed to be not inhibitory to aquatic
microorganisms, if in the toxicity control of a ready biodegradation
test, more than 25% degradation based on CO2 evolution occurred within
14 days (OECD guideline 301). For Fatty acids, C16-18 and C18-unsatd.,
hexaesters with dipentaerythritol (CAS 68604-38-6) a biodegradation test
according to OECD guideline 301B is available (Caduff, 2012). The test
includes a toxicity control, which contains 20 mg/L of the test
substance and 20 mg/L of the reference material (sodium benzoate). The
toxicity control attained 26.7% degradation after 5 days of incubation
(40.9% after 14 d). Hence, the substance is not toxic to aquatic
microorganisms in the toxicity control and the test item concentration
of 20 mg/L can be used as NOEC (14 d).
A detailed reference list is provided in the technical dossier (see IUCLID, section 13) and within CSR.
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