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EC number: 231-701-1 | CAS number: 7691-02-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-09-03 to 2009-09-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- yes
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
46 µl of the test substance, Milli-RO water, synthetic sewage feed (16 ml) and activated sludge (200 ml) were mixed and made up to 500 ml with Milli-RO water in a 1 litre bottle. - Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Preparation of inoculum for exposure: The sludge was coarsely sieved to remove large particles. The sludge was then washed by centrifuging at 1000 g for 10 minutes. The supernatant was decanted and replaced with ISO-medium. The washing step was performed three times. The pH was 7.7 on the day of testing. The batch of sludge was used one day after collection; therefore 50 ml of synthetic sewage feed was added per litre of activated sludge at the end of the collection day. The sludge was kept aerated at test temperature until use.
- Initial biomass concentration: 3.8 g/L - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 3 h
- Post exposure observation period:
- Oxygen consumption was measured and recorded for approximately 10 minutes.
- Test temperature:
- 19.7-20.3°C
- pH:
- 7.6
- Nominal and measured concentrations:
- 100 mg/l (loading rate). Performance of a limit concentration at 100 mg/l is acceptable, because 100 mg/l exceeds the expected concentration in a Sewage Treatment Plant.
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: glass, 300ml oxygen bottles, 1L test bottles
- Aeration: continuous
- No. of vessels per concentration (replicates): two
- No. of vessels per control (replicates): two
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water purified by reverse osmosis (Milli-RO) and subsequently passed over activated carbon and ion-exchange cartridges (Milli-Q)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
After the 3-hour contact time, a well mixed sample of the contents of the reaction mixture was poured into a 300 ml oxygen bottle, and the flask was sealed with an oxygen electrode connected to a recorder, forcing the air out of the vessel. WTW inolab Oxi 730 supplied with a WTW CellOx 325 oxygen electrode, electrolyte type ELY/G
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 100 mg/L only
- Justification for using less concentrations than requested by guideline: No significant inhibition of respiration rate of the sludge was recorded for the test substance at a loading rate of 100 mg/L in both replicates and therefore no further testing was required. - Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Details on results:
- The two controls had a difference in respiration rate of 7%, which is less than the 15% limit required by the guideline for a valid study.
- Results with reference substance (positive control):
- A positive control test with 3, 5-dichlorophenol yielded an EC50 of 8.7 mg/L, which is within the accepted range of 5 to 30 mg/l required by the guideline for a valid study.
- Validity criteria fulfilled:
- yes
- Conclusions:
- An activated sludge respiration inhibition 3 hr EC10 value of >100 mg/L (loading rate) was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Reference
Table 1: Results of the activated sludge respiration inhibition test
Test sample |
Loading rate (mg/l) |
Oxygen conc. at start (mg O2/l) |
Oxygen consumption (mg O2/l/h) |
% Inhibition respiration rate |
pH |
|
|
||||
Initial control |
0 |
6.8 |
30 |
- |
8.2 |
Final control |
0 |
6.5 |
32 |
- |
8.2 |
Dichloro(methyl)(vinyl)silane replicate (1) |
100 |
6.3 |
29 |
6 |
7.6 |
Dichloro(methyl)(vinyl)silane replicate (2) |
100 |
5.8 |
30 |
3 |
7.6 |
|
|
||||
3,5-dichlorophenol |
5 |
- |
- |
38 |
- |
12 |
- |
- |
59 |
- |
|
30 |
- |
- |
72 |
- |
Description of key information
Toxicity to microorganisms: ASRI 3 hour EC10 >100 mg/L (loading rate) (OECD 209), read-across from an analogue substance.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
There are no microorganism toxicity data available for N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine, therefore good quality data for the structurally-related substance dichloro(methyl)(vinyl)silane (CAS 124-70-9), have been read across.
N-(Dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine and dichloro(methyl)(vinyl)silane hydrolyse very rapidly to structurally-related silanol hydrolysis products, dimethylvinylsilanol and methylvinylsilanediol respectively. The other hydrolysis products are ammonia and hydrochloric acid respectively.
N-(Dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine and dichloro(methyl)(vinyl)silane are within a wider group of substances within which in general, there is no evidence of significant toxicity to microorganisms.
This group consists of a number of substances containing a number of different functional groups but specific read-across is between substances with similar functionality. In this case however, this is not possible as no data are available for the relevant group containing silazanes. Therefore, data have been read across from the related group containing alkoxysilanes, silanols, acetoxysilanes and chlorosilanes, etc, where the Si part is of low-biological reactivity, once any hydrolysis is accounted for.
The table below presents microorganism toxicity data available for substances within this group. Additional information is given in a supporting report (PFA, 2013j) attached in Section 13.
Table: Microorganism toxicity data for other relevant substances
CAS |
Name |
Result: E(I)C50 (mg/L) |
Result: NOEC (or EC10/ EC20) (mg/L) |
Guideline Number |
Test method |
Species |
Duration (hours) |
Reliability |
1000-50-6 |
Butylchlorodimethylsilane |
>340 |
|
88/302/EC |
ASRI |
|
3 |
1 |
1066-40-6 |
Hydroxytrimethylsilane |
6670 |
|
OECD 209 and ISO 1892 |
ASRI |
|
Uncertain |
1 |
1185-55-3 |
Trimethoxy(methyl)silane |
>100 |
|
OECD 209 |
ASRI |
|
3 |
1 |
31795-24-1 |
Potassium methylsilanetriolate |
>100 |
|
OECD 209 |
ASRI |
|
3 |
1 |
87135-01-1 |
1,6-Bis(trimethoxysilyl)hexane |
>1000 |
|
OECD 209 |
ASRI |
|
3 |
1 |
17980-47-1 |
Triethoxyisobutylsilane |
>1000 |
≥1000 |
OECD 209 |
ASRI |
|
3 |
1 |
5894-60-0 |
Trichloro(hexadecyl)silane |
>1000 |
≥1000 |
OECD 209 |
ASRI |
|
3 |
1 |
16415-12-6 |
Hexadecyltrimethoxysilane |
>1000 |
|
OECD 209 |
ASRI |
|
3 |
1 |
2943-75-1 |
Triethoxyoctylsilane |
>1000 |
|
OECD 209 |
ASRI |
|
3 |
1 |
16068-37-4 |
4,4,7,7-tetraethoxy-3,8-dioxa-4,7-disiladecane |
>8000 |
8000 |
DIN 38 412, Part 8 (Pseudomonascell multiplication inhibition test) |
growth inhibition test |
P. putida |
16 |
1 |
35435-21-3 |
Triethoxy(2,4,4-trimethylpentyl)silane |
>100 |
|
OECD 209 |
ASRI |
|
3 |
1 |
18395-30-7 |
Trimethoxy(2-methylpropyl)silane |
|
EC101.3 ml/L |
Huls AG method |
oxygen consumption |
P. putida |
5.8 |
2 -don't use to derive PNEC |
142877-45-0 |
Silane, trimethoxy(1,1,2-trimethylpropyl)- |
>1000 |
≥1000 |
OECD 209 |
ASRI |
|
3 |
1 |
13154-25-1 |
Chlorotri(3-methyl-propyl)silane |
>1000 |
100 |
OECD 209 |
ASRI |
|
3 |
2 |
126990-35-0 |
Dicyclopentyldimethoxysilane |
>water solubility |
|
Weight of evidence of three studies: OECD 209//EU C11/Huls AG method (WOE) |
ASRI/ASRI/oxygen consumption P. putida |
|
3 |
1/1/2 |
139147-73-2 |
Silane, dichlorodicyclopentyl- |
>100 |
|
OECD 209 |
ASRI |
|
3 |
1 |
124-70-9 |
Dichloro(methyl)(vinyl)silane |
>100 |
|
OECD 209 |
ASRI |
|
3 |
1 |
75-94-5 |
Trichloro(vinyl)silane |
>100 |
|
OECD 209 |
ASRI |
|
3 |
1 |
1067-53-4 |
Tris(2-methoxyethoxy)vinylsilane |
|
EC10> 2 ml/L |
Huls AG method |
oxygen consumption |
P. putida |
5 |
2 -don't use to derive PNEC |
2768-02-7 |
Trimethoxy(vinyl)silane |
|
EC101.1 ml/L |
Huls AG method |
oxygen consumption |
P. putida |
5 |
2 -don't use to derive PNEC |
In the study with dichloro(methyl)(vinyl)silane (CAS 124-70-9), a 3 hour ASRI EC10 value of >100 mg/L (loading rate) was determined in a reliable study conducted according to an appropriate standard method and in compliance with GLP.
The other hydrolysis product of N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine is ammonia. Typical levels of free ammonia in municipal WWTPs range from approximately 12-50 mg/L in the WWTP collection system (Lehr, 2005. Lehr, Jay; Keeley, Jack; Lehr, Janet Water Encyclopedia, Volumes 1-5. (section 1.4.49). John Wiley & Sons). For the registration substance, the predicted environmental concentrations of the hydrolysis product ammonia in a sewage treatment plant are negligible compared to this typical level (CSR Section 9).
Hydrochloric acid does not have adverse effects on microorganisms in a sewage treatment plant, where the pH is maintained within a favourable range.
Reference:
PFA (2013j). Peter Fisk Associates, STP Microorganism toxicity Main Analogue Group report, PFA.300.003.006
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