Registration Dossier
Registration Dossier
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EC number: 695-745-7 | CAS number: 1079221-49-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 30 mg/kg bw/day
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
One key study is available for this endpoint. In a developmental toxicity study according to OECD testing guideline 414, the test item was administered to female rats by gavage from days 6 through 19 of gestation. On the basis of the effects observed in this study, the LOEL for maternal toxicity was determined at 10 mg/kg/day (effects on maternal body weight) and the NOAEL for fetal and developmental toxicity at 30 mg/kg/day (growth retardation at 100 mg/kg bw/day).
Based on this data, no classification is required for the test item concerning the developmental toxicity endpoint according to the CLP criteria.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
