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EC number: 695-745-7 | CAS number: 1079221-49-0
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From November 05, 2010 to November 16, 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted in compliance with international guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Council Regulation (EC) No. 761/2009, 23 July 2009, Part A, amending Regulation (EC) No. 440/2008: Methods for the determination of physico-chemical properties, A.4 “Vapour pressure”
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- gas saturation method
Test material
- Reference substance name:
- 2-({3-aminopyrazolo[1,5-a]pyridin-2-yl}oxy)ethan-1-ol hydrochloride
- EC Number:
- 695-745-7
- Cas Number:
- 1079221-49-0
- Molecular formula:
- C9 H11 N3 O2, ClH
- IUPAC Name:
- 2-({3-aminopyrazolo[1,5-a]pyridin-2-yl}oxy)ethan-1-ol hydrochloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Results and discussion
Vapour pressureopen allclose all
- Temp.:
- 70.5 °C
- Vapour pressure:
- 0.003 Pa
- Temp.:
- 80.2 °C
- Vapour pressure:
- 0.009 Pa
- Temp.:
- 90 °C
- Vapour pressure:
- 0.031 Pa
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: extrapolated from the vapor pressure curve
Applicant's summary and conclusion
- Executive summary:
The purpose of this study was to determine the vapor pressure of the test item. Several techniques are available to determine the vapor pressure of a test item experimentally. These techniques are described in 92/69/EEC guideline A.4, in the OECD guideline 104 and in the Council Regulation (EC) No. 761/2009, A.4. Based on a model calculation (QSAR) the gas saturation method was applied in this main study. The vapor pressure of the test item was measured at test temperatures of 70 °C, 80 °C and 90 °C and was determined to be 2.6 x 10-3 Pa at 70 °C, 8.7 x 10-3 Pa at 80 °C and 3.1 x 10-2 Pa at 90 °C. The vapor pressure of the test item at 25 °C was extrapolated from the vapor pressure curve and was calculated to be 2.2 x 10-6 Pa at 25 °C.
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