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EC number: 233-658-4 | CAS number: 10294-34-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Boron trichloride
Boron trichloride (BCl3) is rapidly and completely hydrolysed in water to form hydrogen chloride and boric acid. Endpoint data for BCl3 could therefore be replaced by data on the 2 degradation products.
Boric acid
Boric acid is not metabolised in either animals or humans, owing to the high energy level required (523 kJ/mol) to break the B - O bond (Emsley, 1989). Other inorganic borates convert to boric acid at physiological pH in the aqueous layer overlying the mucosal surfaces prior to absorption.Most of the simple inorganic borates exist predominantly as undissociated boric acid in dilute aqueous solution at physiological and environmental pH, leading to the conclusion that the main species in the plasma of mammals is un-dissociated boric acid. Since other borates dissociate to form boric acid in aqueous solutions, they too can be considered to exist as un-dissociated boric acid under the same conditions. Additional support for this derives from studies in which more than 90 % of administered doses of inorganic borates are excreted in the urine as boric acid. Absorption of borates via the oral route is nearly 100 %. For the inhalation route also 100 % absorption is assumed as worst case scenario. Dermal absorption through intact skin is very low with a percent dose absorbed of 0.226 ± 0.125 in humans. Using the % dose absorbed plus standard deviation (SD) for boric acid, a dermal absorption for borates of 0.5 % (rounded from 0.45 %) can be assumed as a worse case estimate.
In the blood boric acid is the main species present and is not further metabolised. Boric acid is distributed rapidly and evenly through the body, with concentrations in bone 2 - 3 higher than in other tissues. Boric acid is excreted rapidly, with elimination half-lives of 1 h in the mouse, 3 h in the rat and < 27.8 h in humans, and has low potential for accumulation. Boric acid is mainly excreted in the urine.
Interspecies differences in toxicokinetics based on data for boron clearance rates in rats versus humans and intraspecies differences in human toxicokinetics based on data on human variability in glomerular filtration rates (GFR) are critical determinates in evaluating human toxicity of boric acid. GFR was identified as the primary determinant of boron clearance rates. A toxicokinetic adjustment factor for boron for human variability is based on the variability in GFR during pregnancy (Dunlop, 1981; Krutzén et al., 1992; Sturgiss et al., 1996) ensuring adequate coverage of the sensitive subpopulation of preeclamptic women (US. EPA 2004; Dourson et al. 1998; Maier et al. 2014).
For comparative purposes, exposures to borates are often expressed in terms of boron (B) equivalents based on the fraction of boron in the source substance on a molecular weight basis. As noted previously, only boric acid and the borate anion are present at environmentally and physiologically relevant concentrations. Read-across between the different boron compounds can be done on the basis of boron (B) equivalents. Conversion factors are given in the table below.
Substance |
Formula |
Conversion factor for equivalent dose of B (multiply by) |
Boric acid |
H3BO3 |
0.1748 |
Boric Oxide |
B2O3 |
0.311 |
Disodium tetraborate anhydrous |
Na2B4O7 |
0.2149 |
Disodium tetraborate pentahydrate |
Na2B4O7•5H2O |
0.1484 |
Disodium tetraborate decahydrate |
Na2B4O7•10H2O |
0.1134 |
Disodium octaborate tetrahydrate |
Na2B8O13·4H2O |
0.2096 |
Sodium metaborate (anhydrous) |
NaBO2 |
0.1643 |
Sodium metaborate (dihydrate) |
NaBO2·2H2O |
0.1062 |
Sodium metaborate (tetrahydrate) |
NaBO2·4H2O |
0.0784 |
Sodium pentaborate (anhydrous) |
NaB5O8 |
0.2636 |
Sodium pentaborate (pentahydrate) |
NaB5O8∙5H2O |
0.1832 |
Hydrogen chloride
Hydrogen chloride and its aqueous solution hydrochloric acid are corrosive and irritating and cause direct local effects on the skin, eye and gastro-intestinal or respiratory tract after direct exposure to sufficiently high concentrations. The chemistry of this substance is well understood; as an inorganic salt it dissolves in water to form hydrogen and chloride ions, both of which are physiological electrolytes.
The absorption, distribution, metabolism and excretion of acids and chloride are well known from human and mammalian physiology. Both ions are regulated within a narrow range to maintain homeostasis.
Complete absorption by oral route can be expected. Dermal absorption of dissolved salts on the other hand is generally limited. Related to extreme water solubility and logP value below 0, the ions are too hydrophilic to cross the lipid rich environment of the stratum corneum. Dermal uptake for such solutions of salts in water will be low.
Concentrated hydrogen chloride is corrosive to skin. At concentrations lower than those that cause corrosion, hydrogen chloride will have no systemic toxicity. Dermal exposures should be controlled on the basis of the potential risk to local effects (irritation, corrosion) to the skin. Concentrations that are lower than those that are irritant will only add to the body’s pool of electrolytes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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