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EC number: 233-658-4 | CAS number: 10294-34-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The decreased pH caused by the formation of HCl during hydrolysis of BCl3 is decisive for the long-term toxicity to fish.
The "LC50" of pH = 6 is best described in pH-units and not by the concentration, in case of more or less buffered aquatic environments.
Key value for chemical safety assessment
Additional information
Relevant information for the 2 degradation products:
Hydrogen chloride:
According to column 2 of Annex IX of REACH "Long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms."
The main effect of hydrochloric acid is to lower the pH. It is not relevant to determine toxicity in terms of mg/L due to the varying buffering capacity of different test systems and different aquatic ecosystems. The constituents of HCl in water are the naturally occurring ions H+ and Cl-. No other than pH effects are expected.
Relevant aquatic organisms need a pH in the range of 6 to 9. If the pH is lowered by the test substance to <6, a toxicity at least to some of the aquatic organisms is foreseen. This is one of the basic assumptions in the EC directive 2006/44/EC on the quality of fresh waters needing protection or improvement in order to support fish life, which state that the pH of the fish water has to be in the range of 6 to 9.
In the case of HCl it is therefore not necessary to perform long-term investigations because a toxic effect can be predicted if the pH falls below 6. There is no "need to investigate further the effects on aquatic organisms".
A pH of 6 corresponds theoretically to NOEClong-term = 0.036 mg HCl/L or 0.039 mg BCl3/L in pure, unbuffered water. In natural water a NOEClong-term >0.039 mg BCl3/L would be obtained, depending on the buffer capacity of the water and the species concerned.
Boric acid:
15 long-term fish toxicity tests are reported in the IUCLID on boric acid. NOECs are ranging from 0.1 to 86 mg B/L, equivalent to 0.57 to 490 mg B(OH)3/L. Most of the results are in the range of 2 to 20 mg B/L, therefore a NOEClong-term = 2 mg B/L, equivalent to 11 mg B(OH)3/L, transcribed to 22 mg BCl3/L is adopted.
Endpoint conclusion:
The decreased pH caused by the formation of HCl during hydrolysis of BCl3 is decisive for the toxicity to aquatic organisms, compared to that of boric acid. Toxic acute and long-term effects can be predicted if the pH is <6, caused by HCl.
A pH of 6 corresponds theoretically to a NOEClong-term = 0.036 mg HCl/L or 0.039 mg BCl3/L in pure, unbuffered water. In natural water a NOEClong-term >0.039 mg BCl3/L would be obtained, depending on the buffer capacity of the water and the species concerned.
Three times this value is considered to reflect more practical conditions for classification: NOEClong-term = 0.12 mg BCl3/L.
For a risk assessment a NOEClong-term of pH = 6 is considered to be the choice for each of the aquatic organisms, as not a systemic, species specific effect is the mechanism of toxicity but the acidity of the medium.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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