Registration Dossier
Registration Dossier
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EC number: 204-341-8 | CAS number: 119-65-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List IV
- Author:
- Smyth HF, Carpenter CP, Weil CS
- Year:
- 1 951
- Bibliographic source:
- Arch.Ind.Hyg.Occup.Med. 4: 119-122
Materials and methods
- Principles of method if other than guideline:
- Primary skin irritation on rabbits is recorded in a 10. grade ordinal series and is based upon the severest reaction that develops on the clipped skin of each of five albino rabbits within 24 hours of the uncovered application of 0.01 ml of undiluted sample or of solutions in water, propylene glycol, or acetone, scored somewhat similarly to the method reported by Draize and associates. Grade 1 shows no reaction whatever from undiluted sample, 2 an average reaction equivalent to a trace of capillary injection, 3 strong capillary injection, 4 slight erythema, 5 strong erythema, edema or slight necrosis, 6 and higher necrosis, where undiluted and Grade 10 indicates necrosis from a 0.01% solution. In Grade 6 a 10 per cent solution gives no reaction more severe than edema, 7 a 1 per cent solution, 8 a 0.1 per cent solution, 9 a 0.01 per cent solution, and 10 any weaker solution.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isoquinoline
- EC Number:
- 204-341-8
- EC Name:
- Isoquinoline
- Cas Number:
- 119-65-3
- Molecular formula:
- C9H7N
- IUPAC Name:
- isoquinoline
- Details on test material:
- - Name of test material (as cited in study report): Iso quinoline
no further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino rabbit
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- open
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.01 ml - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- 5
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 5
- Max. score:
- 10
- Reversibility:
- no data
- Remarks on result:
- other: Grade 5 is described as: strong erythema, edema or slight necrosis after open application of 0.01 ml for 24 hours
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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