Registration Dossier
Registration Dossier
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EC number: 204-341-8 | CAS number: 119-65-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List IV
- Author:
- Smyth HF, Carpenter CP, Weil CS
- Year:
- 1 951
- Bibliographic source:
- Arch.Ind.Hyg.Occup.Med. 4: 119-122
Materials and methods
- Principles of method if other than guideline:
- Penetration of rabbit skin is estimated by a technique closely akin to the one-day, cuff Method of Draize and associates using groups of four male albino New Zealand rabbits weighing 2.5 to 3.5 kg. The fur is removed from the entire trunk by clipping, and the dose is retained beneath an impervious plastic film. Dosages greater than 20 ml/kg cannot be retained in contact with the skin. The animals are immobilized during the 24-hour contact period, after which the film is removed and the rabbits are caged for the subsequent 14-day observation period. Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Isoquinoline
- EC Number:
- 204-341-8
- EC Name:
- Isoquinoline
- Cas Number:
- 119-65-3
- Molecular formula:
- C9H7N
- IUPAC Name:
- isoquinoline
- Details on test material:
- - Name of test material (as cited in study report): Iso quinoline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- New Zealand rabbits weighing 2.5 to 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- The fur is removed from the entire trunk by clipping, and the dose is retained beneath an impervious plastic film. Dosages greater than 20 ml/kg cannot be retained in contact with the skin. The animals are immobilized during the 24-hour contact period, after which the film is removed and the rabbits are caged for the subsequent 14-day observation period.
- Duration of exposure:
- 24 hours
- Doses:
- no data
- No. of animals per sex per dose:
- 4 male animals per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
no further data - Statistics:
- Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the Tables of Weil.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 648 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 417 - < 1 000
- Remarks on result:
- other: LD50 = 0.59 ml/kg according to the publication, the values were converted based on a density of 1.099 g/cm3
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
