Registration Dossier
Registration Dossier
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EC number: 231-106-7 | CAS number: 7439-97-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
EuroChlor (2009): toxicokinetic animal data has shown that mercury does penetrate the placental barrier and accumulates in the fetus when the mother is exposed to metallic Hg vapour. Even though there are inter-species differences, limited epidemiological studies in humans show that there is a transfer from mother to fetus during Hg vapour exposure. Only a few epidemiological studies have been performed and these were mostly in the field of dentistry. As a whole, the limited data presently available provide no conclusive evidence for occupational exposure to mercury vapour being harmful to reproduction. There is no link to an increase in teratogenic or other adverse pregnancy outcomes.
Short description of key information:
The database on reproduction toxicity in animals is very limited. There is one study availbale on the effects of HgCl2 on male fertility in rats. In two studies, the effects of inhalation exposure of dams in relation of the post natal development with respect to behaviour and developmental landmarks are reported. A limited number of epidemiological studies is included in section 7.10 Exposure related observations in humans.
Justification for classification or non-classification
Elemental mercury is classified according to Annex I of Directive 67/548EEC as Repr. Cat. 2 "may cause harm to the unborn child". According to the CLP regulation (EC/1272/2008) it is classified as Repro. 1B – may damage fertility or the unborn child.
Mercury dichloride is classified according to Annex I of Directive 67/548EEC as Repro Cat. 3 "üossible risk for impaired fertility". According to the CLP regulation (EC/1272/2008) it is classified as repro. 2 – suspected of damaging fertility or the unborn child.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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