Registration Dossier
Registration Dossier
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EC number: 221-639-3 | CAS number: 3173-53-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data availlable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Screening-Level Hazard Characterization, Sponsored Chemical Cyclohexyl isocyanate, Supporting Chemical Cyclohexanamine
- Author:
- U.S.EPA
- Year:
- 2 010
- Bibliographic source:
- U.S. Environmental Protection Agency Hazard Characterization Document
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Sprague-Dawley albino rats (5/dose; mixed sexes) were administered cyclohexyl isocyanate
via gavage and observed for 14 days. - GLP compliance:
- not specified
- Remarks:
- no information on GLP in the Hazard Communication Document
Test material
- Reference substance name:
- Cyclohexyl isocyanate
- EC Number:
- 221-639-3
- EC Name:
- Cyclohexyl isocyanate
- Cas Number:
- 3173-53-3
- Molecular formula:
- C7H11NO
- IUPAC Name:
- isocyanatocyclohexane
1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 398, 501, 631 or 794 mg/kg bw
- No. of animals per sex per dose:
- 5 animals/dose, mixed sexes
- Details on study design:
- Sprague-Dawley albino rats (5/dose; mixed sexes) were administered cyclohexyl isocyanate
via gavage at dose levels of 398, 501, 631 or 794 mg/kg-bw and observed for 14 days.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 560 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One male; two males; two males and one female; and three males and one female died at 398, 501,
631 and 794 mg/kg-bw, respectively. Most deaths occurred within 1 day. - Clinical signs:
- other: reduced appetite, decreased activity, increased weakness, collapse and death
- Gross pathology:
- Necropsy findings included lung and liver hyperemia and acute gastrointestinal inflammation.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
