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EC number: 814-217-0 | CAS number: 353258-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1300 (Daphnid Chronic Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
- Cas Number:
- 353258-35-2
- Molecular formula:
- C9H4ClF3N2O2
- IUPAC Name:
- 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid
1
- Specific details on test material used for the study:
- Test substance: IN-QEK31-011
Batch No.: SG0312574
Purity: 98.2%
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
- Remarks:
- Dilution water
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
Test conditions
- Hardness:
- The total hardness ranged from 140 to 146 mg CaCO3/L in control solution samples and from 132 to 150 mg CaCO3/L in the treatment solution samples
- Test temperature:
- 20.2 - 21.0°C
- pH:
- 7.4 - 8.6
- Dissolved oxygen:
- 7.6 - 9.1 mg/L (87 to 103% saturation)
- Salinity:
- The total alkalinity ranged from 148 to 162 mg CaCO3/L in control solution samples and from 124 to 184 mg CaCO3/L in the treatment solution samples
- Conductivity:
- The total conductivity ranged from 332 to 364 μS/cm in control samples, and from 326 to 351 μS/cm in the treatment samples
- Nominal and measured concentrations:
- Nominal: 1.5, 4.4, 13, 40, and 120 mg/L
Measured: 1.40, 4.06, 12.2, 37.7, and 111 mg/L - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 111 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Adult Survival, Reproduction, Adult Length, Adult Dry Weight
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 111 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Adult Survival, Reproduction, Adult Length, Adult Dry Weight
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 111 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Adult Survival
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 21-day NOEC (Daphnia, Adult Survival, Reproduction, Adult Length, Adult Dry Weight): 111 mg/L
21-day LOEC (Daphnia, Adult Survival, Reproduction, Adult Length, Adult Dry Weight): >111 mg/L
21-day EC50 (Daphnia, Adult Survival): >111 mg/L - Executive summary:
The chronic toxicity of the test item to the cladoceran, Daphnia magna, was determined in a 21-day static renewal test. The test was conducted in accordance with OECD Guideline No. 211 and U.S. EPA OPPTS 850.1300 test guidelines. The study was conducted with five target nominal concentrations (1.5, 4.4, 13, 40, and 120 mg/L) and a dilution water control, at a temperature range of 20.2 to 21.0°C. One daphnid was used per replicate with ten replicates per treatment, for a total of 10 organisms per treatment.
The concentration of the test item was measured at initiation, in fresh test solutions on days 9, 14, and 19, and in spent test solutions on days 2, 12, 16, and 21 of the definitive test. Measured concentrations of the test item at initiation were 1.46, 3.97, 12.4, 38.1, and 111 mg/L, or 90 to 97% of nominal. The mean measured concentrations of the test item during the 21-day exposure were 1.40, 4.06, 12.2, 37.7, and 111 mg/L or 92 to 94% of nominal. No residues of the test item were detected in the dilution water control solution above the LOD of 0.0133 mg/L. Recoveries from the QC fortifications ranged from 93 to 106% of the nominal concentrations during the exposure. The biological response results are based on the mean measured concentrations.
Based on survival and mean measured concentrations, the 21-day NOEC and LOEC were 111 and >111 mg/L, respectively, the highest concentration tested. The MATC, based on the survival, could not be calculated. The 21-day EC50 based on immobilization of the first generation daphnids was estimated to be >111 mg/L, the highest concentration tested.
The NOEC and LOEC, based on mean number of live young per surviving adult and mean measured concentrations, were 111 and >111 mg/L, respectively. The MATC, based on the mean number of young per live adult produced during the course of the test, could not be calculated. The 21-day EC10 and EC20, based on number of live young per surviving adult and mean measured concentrations, were estimated to be 114 mg/L (95% CL: 94 and 134 mg/L) and 118 mg/L (95% CL: 110 and 127 mg/L), respectively.
The NOEC and LOEC values, based on mean measured concentrations and adult length, were 111 and >111 mg/L, respectively. The MATC, based on adult length, could not be calculated. The 21-day EC10 and EC20, based on adult body length and mean measured concentrations, were not statistically sound values.
The NOEC and LOEC values, based on mean measured concentrations and adult dry weights, were 111 and >111 mg/L. The MATC, based on adult weight, could not be calculated. The 21-day EC10, based on adult dry weight and mean measured concentrations, was not statistically sound. The 21-day EC20, based on adult dry weight and mean measured concentrations, was estimated to be 116 mg/L (95% CL: 107 and 125 mg/L).
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