Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 465-100-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption, other
- Remarks:
- The log KOC was estimated using an atom/fragment contribution method (Software PCKOCWIN© v 1.66)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- OECD Guideline No. 121 for the testing of chemicals,
adopted on 22 January 2001
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC is performed on an analytical column packed with a commercially available cyanopropyl solid phase, based on a silica matrix, containing lipophilic and polar moieties.
Test material
- Test material form:
- solid: particulate/powder
- Details on test material:
- Batch number: 022401
Constituent 1
- Radiolabelling:
- no
Study design
HPLC method
- Details on study design: HPLC method:
- System: Finnigan Surveyor
Column: Hy Purity Cyano 100*2.1 mm; Lot. No. 6142; SN 0942100X
Column temperature: 35 °C
Mobile phase: 30 % methanol (LiChrosolv, Merck Lot. No. K34906107527)
70 % buffer* pH 7.5 in water
Flow 0.55 mL/min
Injection volume: 10 μL
Detection: UV-absorption at 210 nm
Buffer pH 7.5: 20 mMol/L potassiumdihydrogencitrate in water adjusted with sodium hydroxide to pH 7.5.
The pH of the mobile phase was determined during the run with a pH-meter (InoLab pH Level 2; WTW, Germany).
The dead time t0 was determined by an unretained compound (sodium nitrate; assay > 99.5 %; Lot A474137344; Merck Germany).
According to the guidelines a minimum of six reference points, if possible at least one above and one below the expected value of the test substance should be used. Freshly prepared solutions of six reference compounds in the mobile phase were injected individually to identify their peak in this HPLC-system. Then they were injected simultaneously (before and after the test substance) and the exact retention times were determined in duplicate. The corresponding capacity factors and logarithms of the capacity factors were calculated and plotted as a function of the log KOC.
A linear regression line was calculated from the data of this graph.
The log KOC values of the reference compounds are described in the guidelines.
The test was performed with a freshly prepared solution of 4.8 mg of "STI571 F8" per litre mobile phase.
The retention time of the test substance was determined in duplicate and the capacity factor k was calculated.
Results and discussion
Adsorption coefficient
- Key result
- Type:
- Koc
- Value:
- ca. 3.85
- pH:
- 7.5
- Temp.:
- 35 °C
- Remarks on result:
- other: Main determination of the adsorption coefficient of the partly dissociated base
Results: HPLC method
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration:
- Details of fitted regression line (log k' vs. log Koc):
- Graph of regression line attached
- Average retention data for test substance:
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Although ECHA is providing a lot of online material in your language, part of this page is only in English. More about ECHA’s multilingual practice.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
the-echa-website-uses-cookies
find-out-more-on how-we-use-cookies