Registration Dossier
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EC number: 217-588-1 | CAS number: 1897-45-6
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 Mar 2014 to 20 Mar 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: CIPAC method MT 157.3 (water solubility: flask method)
- GLP compliance:
- yes
- Medium:
- acetone
- Solubility:
- 18 g/L
- Temp.:
- 25 °C
- Medium:
- ethyl acetate
- Solubility:
- 11 g/L
- Temp.:
- 25 °C
- Medium:
- methanol
- Solubility:
- 1.7 g/L
- Temp.:
- 25 °C
- Medium:
- n-octanol
- Solubility:
- 610 mg/L
- Temp.:
- 25 °C
- Medium:
- toluene
- Solubility:
- 56 g/L
- Temp.:
- 25 °C
- Medium:
- other: dichloromethane
- Solubility:
- 31 g/L
- Temp.:
- 25 °C
- Medium:
- other: hexane
- Solubility:
- 180 mg/L
- Temp.:
- 25 °C
- Test substance stable:
- yes
- Details on results:
- The results are presented in 'Any other information on results incl. tables'.
- Conclusions:
- The solubility in seven different organic solvents has been determined. The solubilities determined at 25 °C ranged from 180 mg/L in hexane to 56 g/L in toluene.
- Executive summary:
The solubility of test substance has been determined in seven organic solvents in a method similar to CIPAC method MT 157.3 (water solubility: flask method) and in accordance with GLP as there is no general method available for the determination of the solubility in organic solvents. The solubilities determined at 25 °C and quoted to two significant figures are as follows: acetone 18 g/L; methanol 1.7 g/L; dichloromethane 31 g/L; octanol 610 mg/L; ethyl acetate 11 g/L; toluene 56 g/L and hexane 180 mg/L.
Reference
Table 1: Solubility results
|
Testsubstancedispersed in 40.0 mL of solvent |
Equilibrium time at 25 °C |
Solubility |
|
1 day |
2 days |
|||
Acetone |
3.0537 g |
18.053 g/L |
18.196 g/L |
18 g/L |
Dichloromethane |
3.0124 g |
30.781 g/L |
31.197 g/L |
31 g/L |
Ethyl Acetate |
2.0394 g |
11.315 g/L |
11.501 g/L |
11 g/L |
Hexane |
1.0146 g |
183.5 mg/L |
185.5 mg/L |
180 mg/L |
Methanol |
2.0424 g |
1.707 g/L |
1.700 g/L |
1.7 g/L |
Octanol |
1.0381 g |
624.0 mg/L |
588.5 mg/L |
610 mg/L |
Toluene |
6.0352 |
55.842 g/L |
55.643 g/L |
56 g/L |
Description of key information
The solubility in seven organic solvents ranged from 180 mg/L in hexane to 56 g/L in toluene, CIPAC MT 157.3, Vijayakumar 2014
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 180 mg/L
Additional information
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