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Diss Factsheets
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EC number: 701-328-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1988-08-04 to 1988-08-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline test in compliance with GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Alcohols, C13-15 (odd numbered, branched and linear)
- Molecular formula:
- C13H28O and C15H32O
- IUPAC Name:
- Alcohols, C13-15 (odd numbered, branched and linear)
- Reference substance name:
- Alcohols, C13, branched glycidyl ethers
- Molecular formula:
- C16H32O2
- IUPAC Name:
- Alcohols, C13, branched glycidyl ethers
- Reference substance name:
- [(tridecyloxy)methyl]oxirane
- EC Number:
- 276-765-1
- EC Name:
- [(tridecyloxy)methyl]oxirane
- Cas Number:
- 72689-40-8
- Molecular formula:
- C16H32O2
- IUPAC Name:
- 2-[(tridecyloxy)methyl]oxirane
- Reference substance name:
- Alcohols, C15, branched glycidyl ethers
- Molecular formula:
- C18H36O2
- IUPAC Name:
- Alcohols, C15, branched glycidyl ethers
- Reference substance name:
- [(pentadecyloxy)methyl]oxirane
- EC Number:
- 302-058-5
- EC Name:
- [(pentadecyloxy)methyl]oxirane
- Cas Number:
- 94088-56-9
- Molecular formula:
- C18H36O2
- IUPAC Name:
- 2-[(pentadecyloxy)methyl]oxirane
- Reference substance name:
- secondary reaction products of Oxirane, mono{[C13-15 (odd numbered, linear and branched)-alkyloxy)methyl] derivs.
- Molecular formula:
- UVCB, not applicable
- IUPAC Name:
- secondary reaction products of Oxirane, mono{[C13-15 (odd numbered, linear and branched)-alkyloxy)methyl] derivs.
- Reference substance name:
- unknown constituents
- IUPAC Name:
- unknown constituents
- Test material form:
- liquid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
- Specific details on test material used for the study:
- - Name of test material: Alkyl (C13-C15) glycidylether
- Physical state: Liquid
- Lot/batch No.: DC 1295.3
- Stability under test conditions: Stable
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, CH 4414 Fuellinsdorf / Switzerland
- Age at study initiation: males (14 weeks); females (15 weeks)
- Weight at study initiation: males (2.8 - 2.9 kg); females (2.6 kg)
- Housing: Individually in stainless steel cages equipped with an automatic cleaning and drinking system.
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ±3 °C
- Humidity (%): 40 - 70%
- Air changes (per hr): Air-conditioned with 10 - 15 air changes per hour.
- Photoperiod: 12 hours artificial fluorescent light; 12 hours dark
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 ml per animal
- Duration of treatment / exposure:
- No data
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 2 males and 1 females
- Details on study design:
- The test article (0.1 ml per animal) was placed in the conjunctival sac of the left eye of each animal after gently pulling the lower lid away from the eyeball. The lids were then gently held together for about one second to prevent loss of the test article. The right eye remained untreated and served as the reference control.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 13
- Remarks on result:
- other: Average score: 0
Any other information on results incl. tables
Eye irritation scores:
Results: Toxic symptoms / Mortality No acute toxic symptoms were observed in the animals during the test period, and no mortality occurred. Irritation Alkyl (C13-C15) glycidylether showed a primary irritation score of 0.33, when applied undiluted to the rabbit eye mucosa. Coloration No corrosion of the cornea was observed at any of the measuring intervals. Body weights The body weight gain of all rabbits was similar. Necropsy No necropsy was performed. All animals were killed and discarded. |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The study result indicated that 0.1 ml Alkyl (C13-C15)-glycidylether was not irritating to the rabbit eyes.
- Executive summary:
This study was conducted according to OECD guideline and EU method in order to evaluate the risk potential of Alkyl (C13-C15)–glycidylether to the eyes. 2 male and 1 female rabbits were used in the study. 0.1 ml of the substance was placed in the conjunctiva sac of the left eye of each rabbit and the right eye served as control. Then the eyes were washed after 24 hours. The examination results showed that only slight erythema was observed in the three rabbits after 1h and no abnormalities were observed after 24h, 48h and 72h. The results indicated that the substance was not irritating to the eyes of rabbits.
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