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Diss Factsheets
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EC number: 938-422-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb. 27 2013 - Jun. 6, 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Version / remarks:
- 1984
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.6200 (Earthworm Subchronic Toxicity Test)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes
- Details on preparation and application of test substrate:
- - Method of mixing into soil: directly added
- Test organisms (species):
- Eisenia fetida
- Animal group:
- nematods
- Details on test organisms:
- TEST ORGANISM
- Common name: Earthworm
- Source: Nanjing Earthworm Nursery, China
- Age at test initiation (mean and range, SD): two month old adult
- Weight at test initiation: 377 mg
- Batch: E20130301
ACCLIMATION
- Acclimation period: 24 h - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Test temperature:
- 18 - 22°C
- pH:
- 6.0 - 6.5
- Moisture:
- 35%
- Details on test conditions:
- TEST SYSTEM
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 4
- No. of replicates per control: 4
OTHER TEST CONDITIONS
- Photoperiod: continuous light
- Light intensity: 400 - 800 lux
EFFECT PARAMETERS MEASURED:
mortality, reaction on mechanical stimulus, behavioural and pathological symptoms assessed at days 7 and 14
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: 10, 100, 1000 mg/kg dw - Nominal and measured concentrations:
- Nominal concentration 1000 mg/kg dw
- Reference substance (positive control):
- yes
- Remarks:
- 2-Chloroacetamide, purity >=98.5%
- Key result
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Validity criteria fulfilled:
- yes
- Conclusions:
- A limit test on the acute toxicity of the test item was conducted according to OECD 207. The earthworm Eisenia fetida was used for the test in artificial soil. No mortality was observed within the test period. Therefore, the 14 d-LC50 was determined to be >1000 mg/kg dw and the NOEC was at 1000 mg/kg dw.
Reference
Study design
In this GLP study performed according to OECD GL 207 the acute toxicity of the test item in earthworms was investigated. During this test, the artificial soils was used with the moisture content of the test medium controlled in range of 30 - 36 % with pH values of 6 - 6.5. The test conditions were maintained at 18 - 22°C, a humidity of 35 % and continuous light with intensity of 400 - 800 lux.
Results
No dead earthworms were observed in treatments and control. During test all animals remained in soil. Based on the result of range-finding test and the Limit Test, the 14 d-LC50 of the test item in the artificial soil was determined to be greater than 1000 mg/kg dry weight soil. The highest concentration causing no mortality (14 d-LC0) was 1000 mg/kg dry weight soil.
Conclusion
No mortality was observed within the test period. Therefore, the 14 d-LC50 was determined to be >1000 mg/kg dw and the NOEC was at 1000 mg/kg dw.
Description of key information
The Toxicity to soil macroorganisms except arthropods was studied in a GLP compliant OECD TG 207 assay. No mortality was observed within the test period. Therefore, the 14 d-LC50 was determined to be >1000 mg/kg dw and the NOEC was at 1000 mg/kg dw.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 1 000 mg/kg soil dw
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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