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EC number: 281-468-5 | CAS number: 83950-14-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October-November 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-[2-[4-[benzylmethyl(ethyl)amino]phenyl]vinyl]-1-(2-hydroxyethyl)pyridinium acetate
- EC Number:
- 281-468-5
- EC Name:
- 4-[2-[4-[benzylmethyl(ethyl)amino]phenyl]vinyl]-1-(2-hydroxyethyl)pyridinium acetate
- Cas Number:
- 83950-14-5
- Molecular formula:
- C24H27N2O.C2H3O2
- IUPAC Name:
- 4-[2-[4-[benzylmethyl(ethyl)amino]phenyl]vinyl]-1-(2-hydroxyethyl)pyridinium acetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann Borchen Germany
- Strain: Wistar TNO/W
- Age at study initiation: males 9 weeks. females 14 weeks
- Weight at study initiation: males 157-185 g, females 151-176 g
- Fasting period before study: yes 16 hours pre-dosing and 4 hours post-dosing
- Housing: 5/sex in Macrolon type III cages
- Diet: Altromin R3 1324 (Altromin GmbH Lage, Germany) ad libitum
- Water: tap water ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 1.5 °C
- Humidity (%): 60 °C 5 %
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 0.31, 1.0, 1.25, 1.6, 2.5 and 5.0 mL/kg
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: clinical signs and mortality twice daily
- Body weight: on day 0, 7 and 14
- Necropsy: on all animals - Statistics:
- probit analyses
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1.56 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1.38 - <= 1.8
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 700 mg/kg bw
- Based on:
- test mat.
- Mortality:
- males: 0, 0, 1, 1 ,4 and 5 at 0.31, 1.0, 1.25, 1.6 2.5 and 5.0 mL/kg
females: 0, 0, 2, 3, 5 and 5 at 0.31, 1.0, 1.25, 1.6 2.5 and 5.0 mL/kg
Mortality was within 4 hours after dosing - Clinical signs:
- at 1.0 mg/L: nausea in one male and one female
at 1.25 mg/L: diarrhea, nausea and sedation in all animals
at 1.6 and above: diarrhea, nausea, sedation and convulsions in all animals - Body weight:
- no data
- Gross pathology:
- In decedents: orange discoloration prevented examination
in survivors: no findings
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 in rats is 1700 mg/kg bw
- Executive summary:
Rats (5/sex/dose) received a single dose of the substance by gavage ( 0.31, 1.0, 1.25, 1.6, 2.5 and 5.0 mL/kg). Mortality (within 4 hours after dosing) was 0, 0, 3, 4 ,9 and 10 at 0.31, 1.0, 1.25, 1.6, 2.5 and 5.0 mL/kg. During the 14 day observation period diarrhea, nausea, sedation and convulsions were observed in surviving animals. Necropsy of decedents was not possible due to orange discoloration of the organs. In survivors no abnormalities were recorded. The LD50 (as assessed by the author of the report) is 1700 mg/kg bw.
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