Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-889-8 | CAS number: 128-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Density
Administrative data
Link to relevant study record(s)
- Endpoint:
- relative density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Principles of method if other than guideline:
- The test is conducted in accordance with the procedure described in EU Regulation (EC) 440/2008, Annex Part A test A.3 and OECD Test Guideline 109.
The relative density of solids or liquids is the ratio between the mass of a volume of substance to be examined, determined at 20°C, and the mass of the same volume of water, determined at 4°C. The relative density has no dimension.
The density, ρ, of a substance is the quotient of the mass, m, and its volume, v.
The density, ρ, is given, in SI units, in kg/m3.
For solids or liquids, pycnometers of various shapes and with known volumes may be employed. The density is calculated from the difference in weight between the full and empty pycnometer and its known volume. The tests are run at a constant temperature, preferably 20°C, and at least two measurements are generally performed. - GLP compliance:
- no
- Type of method:
- pycnometer method
- Specific details on test material used for the study:
- Batch FPAC1822263.
Substance tested is a 56%wt solution of calcium docusate in corn oil. Attempts were made to obtain neat/pure test material but the substance is extremely difficult to handle in the neat form. The form of the substance tested reflects how the substance will be supplied and placed on the market. - Key result
- Type:
- relative density
- Density:
- 1.021
- Temp.:
- 20 °C
- Type:
- density
- Density:
- 1.021 g/cm³
- Temp.:
- 20 °C
- Conclusions:
- Mean result from 3 runs:
Relative density = 1.021 @ 20°C
Density = 1.021 g.cm-3 @ 20°C - Executive summary:
The density of docusate calcium (56%w/w in corn oil) was determined in accordance with the pycnometer procedure described in EU Regulation (EC) 440/2008, Annex Part A test A.3 and OECD Test Guideline 109.
Mean result from 3 runs:
Relative density = 1.021 @ 20°C
Density = 1.021 g.cm-3 @ 20°C
- Endpoint:
- density
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- March to April 2010
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- Data has been read across from a structurally similar substance (Sodium Docusate). See read-across justification documents in section 13 (to be updated to include calcium docusate divalent salt)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.3 (Relative Density)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- pycnometer method
- Type:
- density
- Density:
- 1.146 g/cm³
- Temp.:
- 27.4 °C
- Executive summary:
The density of Docusate Soduium was determined accroding to EC A.3 and OECD 109 at 20.3°C using a helium pygnometer. The density °C was determined to be of 1.146 ± 0.001 g·cm-3(=1146 kg/m-3) and the relative density is 1.146 ± 0.001.
The relative density value of 1.146 for sodium docusate is used as a read-across supporting study for calcium docusate.
The obtained value is considered relevant and reliable.
Referenceopen allclose all
Four independent measurements were performed at 20.3 °C with following results:
1.1475; 1.1472; 1.1454; 1.1451 g·cm-3
The mean value was : 1.146 ± 0.001 g·cm-3
The density °C was determined to be of 1.146 ± 0.001 g·cm-3 (=1146 kg/m-3) and the relative density is 1.146 ± 0.001.
Description of key information
The density of docusate calcium (56%w/w in corn oil) was determined in accordance with the pycnometer procedure described in EU Regulation (EC) 440/2008, Annex Part A test A.3 and OECD Test Guideline 109.
Mean result from 3 runs:
Relative density = 1.021 @ 20°C
Density = 1.021 g.cm-3 @ 20°C
Key value for chemical safety assessment
- Relative density at 20C:
- 1.021
Additional information
The density of the read across substance Docusate Sodium was determined in a non-GLP Klimisch 1 key study (Holzschuh 2010) according to methods EC A.3 and OECD 109 at 20.3°C using a helium pygnometer. The density was determined to be of 1.146 ± 0.001 g·cm-3 (=1146 kg*m-3). The corresponding relative density is 1.146 ± 0.001.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.