Registration Dossier
Registration Dossier
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EC number: 204-889-8 | CAS number: 128-49-4
Surface tension
Administrative data
Link to relevant study record(s)
- Endpoint:
- surface tension
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- March to April 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline compliant study
- Justification for type of information:
- Data has been read across from a structurally similar substance (Sodium Docusate).
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.5 (Surface Tension)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 115 (Surface Tension of Aqueous Solutions)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- plate method
- Surface tension:
- 30.65 mN/m
- Temp.:
- 20 °C
- Conc.:
- 1 g/L
- Executive summary:
The surface tension was determined with the plate method according to EC A.5 and OECD 115. The surface tension of a 1g/L solution of Docusate Sodium was 30.65 +/- 0.1 mN·m-1.
In the absence of experimental data for calcium docusate, the surface tension result for sodium docusate is applied as read-across.
The result is considered relevant and reliable for the further risk assessment.
Reference
The Single results were :
30.8103 mN/m,
31.0054 mN/m and
31.0786 mN/m
The mean value was 30.96 mN/m
Correction factor: 0.9899
Final result: 30.65 +/- 0.1 mN·m-1
Description of key information
30.65 mN/m
Key value for chemical safety assessment
- Surface tension:
- 30.65
- in mN/m at 20°C and concentration in mg/L:
- 1 000
Additional information
In the Klimisch 1 key study (Holzschuh 2010) the surface tension was determined with the plate method according to EC A.5 and OECD 115. The surface tension of a 1g/L solution of Docusate Sodium was 30.65 +/- 0.1 mN·m-1.
In the absence of experimental data for calcium docusate, the surface tension result for sodium docusate is applied as read-across.
The result is considered relevant and reliable for the further risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
