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Diss Factsheets
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EC number: 253-981-4 | CAS number: 38517-37-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From January 26, 2016 to February 09, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Batch no.: 3837
Purity: 25.5% in water
Solubility: soluble in water - Analytical monitoring:
- yes
- Remarks:
- Measurement of analytical total organic carbon (TOC) concentrations with a TOC analyser
- Details on sampling:
- - Samples, properly diluted with deionised water with low TOC contents, have been analysed by means of an integrated sampling system directly from vials containing 40 ml volume. For each sample under test the corresponding blank is analysed.
- Samples were stable over the duration of the test (96 h). - Vehicle:
- no
- Details on test solutions:
- Range-finding test: 5 different concentrations of the active ingredient (from 0.1 to 1000 mg/L).
Definitive test: solution at 100 mg/L of the active ingredient in water. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Length : 2 +/- 1 cm
Biomass-density: < 1 g/L
Number of animals: 7/tank
Supplier: Aquarium Center
Feeding: feedstuff in flakes - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 250 mg CaCO3/L
- Test temperature:
- 23 +/- 2°C
- pH:
- 7.5 - 8.1
- Dissolved oxygen:
- 61 - 74%
- Nominal and measured concentrations:
- Range finding test: 5 different concentrations of the active ingredient (from 0.1 to 1000 mg/L).
Definitive test: solution at 100 mg/L of the active ingredient in water. - Details on test conditions:
- Aeration: continuous with porous stones
(Tanks have been lighted with white light lamps with 12 h photoperiod daily).
NB: The water used has been allowed to stabilize for 48 h to greatly reduce chlorine presence. - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Details on results:
- The test substance was considered stable, because the TOC values at the end of the test remain in the required range (80 -120%) respect to the initial values.
- Results with reference substance (positive control):
- -
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the 96 h LC50 of the substance in Brachydanio rerio was determined to be >100 mg a.i./L.
- Executive summary:
A study was conducted to determine the short-term toxicity of the substance to fish according to OECD Guideline 203, in compliance with GLP. Brachydanio rerio (7/group) were exposed to the test substance at a concentration of 100 mg/L for 96 h. The total organic carbon (TOC) concentrations were measured with a TOC analyser and the test substance was considered stable over the duration of the test. No mortalities or symptoms (visible abnormalities) were observed during the test. Under the study conditions, the 96 h LC50 of the substance in Brachydanio rerio was determined to be >100 mg a.i./L (Giarei, 2016).
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 100 mg/L
Additional information
A study was conducted to determine the short-term toxicity of the substance to fish according to OECD Guideline 203, in compliance with GLP. Brachydanio rerio (7/group) were exposed to the test substance at a concentration of 100 mg/L for 96 h. The total organic carbon (TOC) concentrations were measured with a TOC analyser and the test substance was considered stable over the duration of the test. No mortalities or symptoms (visible abnormalities) were observed during the test. Under the study conditions, the 96 h LC50 of the substance in Brachydanio rerio was determined to be >100 mg a.i./L (Giarei, 2016).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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