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EC number: 253-981-4 | CAS number: 38517-37-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is readily biodegradable
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From December 30, 2015 to February 22, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EN ISO 10634:1995 - Guidance for the preparation and treatment of poorly soluble organic compounds for the subsequent evaluation of their biodegradability in an aqueous medium
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Quality Assesment Statement is on page 4 of the attached report
- Specific details on test material used for the study:
- Batch no.: 3837 supplied by the sponsor
Purity: 25.5% in water (water solution)
Solubility: soluble in water
Storage condition of test material: room temperature (15 °C - 25 °C)
Stability and homogeneity of the test material in the vehicle/solvent under test conditions (e.g. in the exposure medium) and during storage: stable for 12 months minimum
Solubility: soluble and stable in water
Reactivity of the test material with the incubation material used (e.g. plastic ware): not reactive
pH (20 °C) = 6.22
Composition in C, H and N: C=12.88%, H= 9.80%, n= 0.97%, nominal concentration 20.78 mg/l TOC.
More information can be found on the attached report - Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, predominantly domestic, non-adapted
- Remarks:
- If inoculum was pre-adapted, this would be written on the report, what is not. Substance is not widely used, annual production is lower than 30 ton. It is not ubiquitous in consumer products.
- Details on inoculum:
- - A sample of aerobic sludge that has been selected by the mixed treatment plant of urban (about 66%) and industrial (about 34%) liquid sewage situated at San Rocco - Monza (MI).
- Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): A sample of aerobic sludge that has been selected by the mixed treatment plant of urban (about 66%) and industrial (about 34%) liquid sewage situated at San Rocco - Monza (MI). Inoculum was not preadapted. See attached report for more information.
-In the laboratory the sampled mudshave been mixed and let settle, keeping them in aerobic conditions. The mud samples, before their use, have been analysed to checkits ability to form colony.
Bacterial count in the ud was 1.99x10exp6 cell/ml (see Colony report attached).
10.4 ml of this mud were put in 10000 ml and then in the final vessels of test there were 1:1000 of the starting mud , so 10exp3cell/ml. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 20.78 mg/L
- Based on:
- TOC
- Parameter followed for biodegradation estimation:
- other: total inorganic carbon (TIC)
- Remarks:
- with a TOC analyser
- Details on study design:
- Bottles preparation:
- Medium preparation.
- 20 bottles for the test substance, for the blank, and for the reference substance to which the inoculum of the muds has been added (in five replicate bottles).
Everything was done using deionized water.
- Incubation at 25 +/- 2°C for 28 days (under stirring in darkness). - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- Purity 99%, used at a nominal concentration of 20.22 mg/L of organic carbon (TOC)
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- 87
- Sampling time:
- 14 d
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- 95
- Sampling time:
- 28 d
- Details on results:
- - Total biodegradation (Dt) has been calculated using the equation:
Dt = (TICt - TICb)/TOCi*100
(TOCi = concentration of organic carbon of the test substance, in mg, added at the beginning).
- A substance is considered biodegradable when its level of biodegradability is at least 60%, within a period of 28 days. - Results with reference substance:
- Percentage of biodegradation (benzoic acid, sodium salt) after 14 days: 95
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Under the study conditions, the substance was considered to be readily biodegradable under aerobic conditions.
- Executive summary:
A study was conducted to determine the biodegradation of the substance in water according to OECD Guideline 310 and EN ISO 10634:1995, in compliance with GLP. Aerobic sludge that has been selected by the mixed treatment plant of urban (about 66%) and industrial (about 34%) liquid sewage has been exposed to the test substance for 28 d at 25°C (under stirring in darkness). Total inorganic carbon (TIC) was measured using an automatic TOC analyser and total biodegradation (Dt) was then calculated (Dt = (TICt - TICb)/TOCi*100). The biodegradation of the test substance was 87% and 95%, after 14 and 28 d, respectively. The percentage of biodegradation for the positive control substance, i.e. benzoic acid, sodium salt after 14 d was 95. The experiment was considered valid. Under the study conditions, the substance was considered to be readily biodegradable under aerobic conditions (Giarei, 2016).
Table 1. Results
Check point (days) | % of biodegradation; Reference substance | % of biodegradation; Test substance |
0 | 0 | 0 |
1 | 16 | 14 |
6 | 101 | 91 |
14 | 95 | 87 |
21 | 96 | 80 |
28 | 105 | 95 |
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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