Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-543-9 | CAS number: 2802-68-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- testing lab.
Test material
- Reference substance name:
- Hydrogen trifluoromethoxyborate(1-), compound with methanol (1:1)
- EC Number:
- 220-543-9
- EC Name:
- Hydrogen trifluoromethoxyborate(1-), compound with methanol (1:1)
- Cas Number:
- 2802-68-8
- Molecular formula:
- CH4O.CH3BF3O.H
- IUPAC Name:
- hydrogen trifluoro(methanolato)borate(1-) methanol (1:1)
- Details on test material:
- Name of the test substance used in the study report: Borfluorid-Methanol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Mean body weight: 4 kg; age: young adult rabbits
The animals were identified via ear tattoo.
Singly housing in stainless steel wire mesh cages with grating (floor area: 3000 cm2).
The animals were housed in fully air-conditioned rooms with a room temperature of 20 - 24°C and a relative humidity of 30 - 70%. The day/night rhythm was 12 h light and 12 h dark.
A standardized animal laboratory diet (a. 130 g/animal/day) as well as tap water (250 ml/animal/day) were offered.
Acclimatization period: at least 1 week
Weight determination: shortly before application of the test substance
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 3 min and 1 h
- Observation period:
- 3 min application: 8 days
1 h application: 24 h - Number of animals:
- 3 min application: 3
1 h application: 2 - Details on study design:
- At least 24 hours before study start, the fur was removed by clipping the dorsal of the trunk of the animals. Only animals with healthy intact skin have been used.
The test substance was applied in a signle dose to the intact untreated skin. The test patches were secured in position with a semiocclusive dressing. The test substance was removed at the end of the exposure period with Lutrol and Lutrol/water (1:1).
Application volume: The test patches (2.5 x 2.5 cm) were moistened with a dose of 0.5 ml of the unchanged liquid test substance.
Application site: upper third of the back or flanks
Observation period: 8 day (3 min application) resp. 72 h (1 h application)
Readings: 1 h, 24 h, 48 h, 72h and 8 d after removal of the test patches.
A check was made twice each working day and once on weekends and on public holidays for general observations and for any dead or moribund animals.
Additional investigation: Because the visual assessment of the skin did not allow a statement with respect to the depth of necrotic changes, a cross incision of the treated skin has been performed after the animal was killed at study termination.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 1.2
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: 3 min application
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 0.2
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other: 3 min application
- Irritant / corrosive response data:
- After the application of 1 hour the following findings were observed: The average score for irritation could not be calculated because of visual necrosis and therefrom rsulting study termination at 24 hours after removal of the test patchtes.
Visual necrosis was observed 1 hour after removal of the test patches, thus, the observation period was terminated after 24 hours. The necrotic change of the skin was assessd by macroscopic pathology indicating fulll-thickness necrosis.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Classification: corrosive (causes burns)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.