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EC number: 220-543-9 | CAS number: 2802-68-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Hydrogen trifluoromethoxyborate(1-), compound with methanol (1:1)
- EC Number:
- 220-543-9
- EC Name:
- Hydrogen trifluoromethoxyborate(1-), compound with methanol (1:1)
- Cas Number:
- 2802-68-8
- Molecular formula:
- CH4O.CH3BF3O.H
- IUPAC Name:
- hydrogen trifluoro(methanolato)borate(1-) methanol (1:1)
- Details on test material:
- Name of the test substance used in the study report: Borfluorid-Methanol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult animals with a comparable body weight were used.
The animals were identified using cage cards and group identification by tail marking.
One animal per cage (type: stainless steel wire mesh cages, DK-III).
The animals were housed in fully air-conditioned rooms with a room temperature of 20 - 24°C and a relative humidity of 30 - 70%. The day/night rhythm was 12 h dark and 12 h light.
A standardized animal laboratory diet as well as tap water were available ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- Reason for the vehicle: The test substance is sensitive to hydrolysis.
Form of administration: solujtion
Concentrations used were 4 and 40 g/100 ml
Administration volume: 5 ml/kg - Doses:
- 200 and 2000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Acclimatization period for at least 1 week.
Observation period: 14 days
Body weight determination shortly before administration, weekly thereafter and at the end of the study (before fasting period).
Recording of signs and symptoms several times on the administration day, at least once each working day for the individual animals.
A check concerning general observations and mortality was made twice each working day and one on weekends and on public holidays.
Necropsy at the last day of the observation period. Withdrawal of food at least 16 hours before killing with CO2; then necropsy with gross-pathological examination (necropsy of all animals that die as soon as possible).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Mortality:
- 200 mg/kg: no mortalities
2000 mg/kg: all animals died within 3 hours after administration - Clinical signs:
- other: 200 mg/kg: impaired general state and dyspnea 2000 mg/kg: poor general state, dyspnea, apathy, staggering, ataxia, paresis and cyanosis The surviving animals appeared normal 1 or 4 days after administration.
- Gross pathology:
- 2000 mg/kg: hemorrhages in the mucosaof the glanduar stomach and substance discoloration of contents in the small intestines.
200 mg/kg: no pathologic findings noted
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- No mortality was observed at 200 mg/kg during the 14-day observation period, wheras all animals in the 2000 mg/kg group died shortly after administration. The data indicate that the LD50 is higher than 300 mg/kg, marking the classification threshold between categories 3 and 4. As the LD50 is clearly below 2000 mg/kg, the substance is classified into category 4.
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