Lauric acid, monoester with propane-1,2-diol

PBT assessment

PBT assessment: overall result

Reference

Name:

RM1004755

Type of composition:

legal entity composition of the substance

State / form:

liquid

> 85 - <= 100 % (w/w)

Reference substance:

RM1004755

Reference substance:

RM1004755

Reference substance:

RM1004755

This impurity is considered relevant for the classification and labelling of the substance

Reference substance:

RM1004755

This impurity is considered relevant for the classification and labelling of the substance

PBT status:

the substance is not PBT / vPvB

Justification:

Persistence:

RM1004755 is considered to be readily biodegradable based on the test conducted in 2015 in accordance with OECD 301F(Manimetric respirometry test) and GLP compliant. The read across substance FX 511 is also readily biodegradable and this result is based on the test conducted in 2012 in accordance with OECD 301B method (CO2 Evolution test).
The results of the read across substance and the test on the substance itself confirms that RM1004755 is readily biodegradable and does not fulfil the criteria for persistency.

Bioaccumulation:

EPISuite predicted that the majority of RM1004755 (83%) would be removed in wastewater treatment and it is expected, from the results of the biodegradability laboratory test, that the substance would breakdown under wastewater treatment and in the aquatic environment. Separately, the fugacity model predicted that if released directly to the environment, then a small proportion (23%) may be likely to partition to the water column. This is based on a conceptual model of runoff from soil. It is this proportion (23%) that may be available for uptake by aquatic organisms (fish), but as the substance is readily biodegradable, it is concluded that the substance is unlikely to be bioaccumulative.

QSAR modelling in EpiWeb and VEGA models were performed (Meylan, Caesar and KNN) and all four modelled approaches predicted that RM1004755 would not be bioaccumulative.

The results from the VEGA models are indicated to be of low reliability as the models’ accuracy for similar molecules in their training set is not optimal, experimental values disagree with predicted values for similar molecules, and the maximum error in prediction of similar molecules was high. However, the CAESAR model does state that the carbonyl residue in the test substance is present in a very large number of non-bioaccumulative compounds (even when the Log Kow is higher than 3) and the OH polar group increases hydrophilicity. The property of ready biodegradability and the potential for removal in wastewater treatment – total removal of 83.11% is predicted in EpiWeb QSAR modelling – builds the evidence of not bioaccumulative (not B) for RM1004755. 

 

The QSAR modelling results are as follows:

1.           QSAR using EpiWeb BCFBAF v 3.01 model: Log BCF of 1.724 (BCF 52.92 l/kg wet wt);

2.           QSAR using Meylan 1.0.3 model: Log BCF of 1.41 (BCF 25.7 l/kg);

3.           QSAR using CAESAR 2.1.14 model: Log BCF of 2.01 (BCF 102.4 l/kg); and

4.           QSAR using KNN 1.1.0 model: Log BCF of 1.67 (BCF 46.77 l/kg).

 Based on the information available, including modelled data, we would consider that the substance does not meet the bioaccumulation criterion (B) of a BCF in aquatic species that is higher than 2000. 

According to ECHA Guidance on information requirements and chemical safety assessment (June 2017), Chapter R.11, Figure 11 -4: Integrated testing strategy for B-assessment, no further testing is

required for the bioaccumulation criterion.

Toxicity:

Based on available reliable data for RM1004755 the short-term acute toxicity (LC50 or EC50) to aquatic organisms is <0.1 mg/L, however, even though RM1004755 is not considered to be Persistent in the environment (as it is readily biodegradable) acute toxicity data alone cannot be used to reach a conclusion

It is therefore concluded that the substance is potentially T according to the toxicity (T) criterion as laid down in Annex XIII of Regulation (EC) No 1907/2006.

The overall conclusion is that RM1004755 does not meet the PBT or vPvB criteria. No further testing is required.