Registration Dossier
Registration Dossier
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EC number: 226-901-0 | CAS number: 5538-94-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- USDA Regulation 362.8, Title 7, Chapter III, Part 362, Code of Federal Regulations; Paragraph 362.116.
- Deviations:
- not specified
- Principles of method if other than guideline:
- - Principle of test: Inhaltion of substance for 1 hour.
- Short description of test conditions: Not specified.
- Parameters analysed / observed: Not specified. - GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Dimethyldioctylammonium chloride
- EC Number:
- 226-901-0
- EC Name:
- Dimethyldioctylammonium chloride
- Cas Number:
- 5538-94-3
- Molecular formula:
- C18H40NCl
- IUPAC Name:
- dimethyldioctylazanium chloride
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 10 mg/L
- No. of animals per sex per dose:
- 5 animals/sex/dose.
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 10 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- not determinable
- Mortality:
- None.
- Clinical signs:
- other: Not specified.
- Body weight:
- Not specified.
- Gross pathology:
- Not specified.
Any other information on results incl. tables
| Dose | Animals | No. | Survivors |
| 10 mg/L/1 hour | Male rats | 5 | 5 |
| 10 mg/L/1 hour | Female rats | 5 | 5 |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The LD50 is >10 mg/L air based on an acute inhalation toxicity study (1 hour exposure) in which no animals died.
- Executive summary:
In an acute toxicity study the substance was administered to mice (5 animals/sex/dose) by inhaltion at a concentration of 10 mg/L air for 1 hour. No animals died. The inhalation LD50 in rats is >10 mg/L air.
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