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Physical & Chemical properties

Water solubility

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Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2017-07-20 to 2017-07-27
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
> 727 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
12.7

Table 1: Water solubility test

Experiment 1 Experiment 2
x (g) test item added to
5 mL water		 Observations x (g) test item added to
5 mL water		 Observations
1.00003 clear liquid phase 1.00211 clear liquid phase
2.00008 clear liquid phase 2.00208 clear liquid phase
3.00010 clear liquid phase 3.00275 clear liquid phase
4.00474 clear liquid phase 4.00245 clear liquid phase
5.00476 clear liquid phase 5.00328 clear liquid phase
6.19087 clear liquid phase 6.00340 clear liquid phase
7.18752 clear liquid phase 7.00322 clear liquid phase
8.18571 clear liquid phase 8.00309 clear liquid phase
9.18565 precipitation
of test item		 9.00300 precipitation
of test item

The pH value of the clear liquid phase at the ca. 727 g/L (8.00239 g and 8.00124 g test item / 11 mL) concentration level was determined to be 12.7.

Conclusions:
Based on the preliminary test the water solubility of the test item was determined to be > 727 g/L (ca. 8 g / 11 mL) at 20.0 °C.
Executive summary:

A study was conducted according to OECD TG 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840 in order to determine the water solubility. During the main test by using the shake flask method no saturated solution could be prepared. At the saturated concentration there was no liquid phase in the sample, therefore, the determination of the concentration was not feasible. Based on these observations the preliminary test with visual detection was applied for the estimation of the water solubility. The water solubility was determined to be > 727 g/L (ca. 8 g / 11 mL) at 20.0 °C.

Description of key information

Based on the preliminary test the water solubility of the test item was determined to be > 727 g/L (ca. 8 g / 11 mL) at 20.0 °C.

Key value for chemical safety assessment

Additional information

A study was conducted according to OECD TG 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840 in order to determine the water solubility (reference 4.8-1). During the main test by using the shake flask method no saturated solution could be prepared. At the saturated concentration there was no liquid phase in the sample, therefore, the determination of the concentration was not feasible. Based on these observations the preliminary test with visual detection was applied for the estimation of the water solubility. The water solubility was determined to be > 727 g/L (ca. 8 g / 11 mL) at 20.0 °C.