Disodium L-tyrosinate

Boiling point

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

boiling point

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance is a solid which decomposes before boiling

Reference 2

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

2017-06-27

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

not applicable

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

not applicable

GLP compliance:

yes (incl. QA statement)

Type of method:

method according to Siwoloboff

Key result

Decomposition:

yes

Remarks on result:

not determinable

Determination of the boiling point of the test item according to the EC A.2 and OECD 103 guideline using a method following Siwoloboff with automatic photo-electrical detection was technically not feasible because the capillary could not be inserted into the sample tube. Starting the measurement at the melting point of test item (334.7 °C), a small amount of yellow melt appeared at the bottom of the capillary, but most of the sample was hardened and its colour became brown. The test item moved towards the upper part of the sample tube. Therefore, the capillary could not be inserted into it.

Conclusions:

The test item started to decompose immediately after melting.

Executive summary:

The performance of a study according to OECD TG 102 and EU method A.2 in order to determine the boiling point of the test item by using Siwoloboff method was technically not feasible. After melting of the test item most of the sample was hardened and the colour became brown. The test item moved towards the upper part of the sample tube and therefore the capillary could not be inserted into it. Based on these observations it was concluded that the test item started to decompose immediately after melting.

Description of key information

The test item started to decompose immediately after melting.

Additional information

The performance of a study according to OECD TG 102 and EU method A.2 in order to determine the boiling point of the test item by using Siwoloboff method was technically not feasible. After melting of the test item most of the sample was hardened and the colour became brown. The test item moved towards the upper part of the sample tube and therefore the capillary could not be inserted into it. Based on these observations it was concluded that the test item started to decompose immediately after melting (references 4.3-1 and 4.3-2).